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Comparative study of rectal misoprostol to oxytocin infusion in preventing postpartum haemorrhage after caesarean section

Comparative study of rectal misoprostol to oxytocin infusion in preventing postpartum haemorrhage after caesarean section
Comparative study of rectal misoprostol to oxytocin infusion in preventing postpartum haemorrhage after caesarean section
Aims: This comparative study aimed to compare the efficacy of rectal misoprostol to oxytocin infusion in preventing primary postpartum haemorrhage after caesarean section.

Methods: Fifty pregnant women with identifiable risk factors for post-partum haemorrhage who delivered baby by caesarean section were randomized to receive 600 ?g rectal misoprostol and a placebo infusion intravenously or placebo rectally and a 20 iu oxytocin infusion. Post-operative blood loss four hours after surgery was estimated by application of pads of known weight.

Results: The mean immediate four hours post-operative blood loss was not significantly different between the rectal misoprostol and oxytocin infusion group (100.08 ± 24.85 ml versus 108.20 ± 29.93 ml; p =0.144) and the change between the pre-operative and post-operative hematocrit was similar.

Conclusions: Post-caesarean section rectal misoprostol has comparative efficacy to oxytocin infusion in preventing post-partum haemorrhage. It is recommended for use as alternative uterotonic in settings where there is low refrigeration capacity.
caesarean section, misoprostol, oxytocin infusion, postpartum haemorrhage
1999-9623
34-37
Adanikin, Abiodun, Idowu
7c475e5b-223b-4d26-9b60-85b32af15727
Orji, E.
0a1e5e74-5d6a-4b54-9554-a9306fa42c98
Adanikin, P.O.
bdf5a553-be00-4a84-80e7-e5e2602c3113
Olaniyan, O.
11c64ec2-47b3-43ce-acea-8131db501974
Adanikin, Abiodun, Idowu
7c475e5b-223b-4d26-9b60-85b32af15727
Orji, E.
0a1e5e74-5d6a-4b54-9554-a9306fa42c98
Adanikin, P.O.
bdf5a553-be00-4a84-80e7-e5e2602c3113
Olaniyan, O.
11c64ec2-47b3-43ce-acea-8131db501974

Adanikin, Abiodun, Idowu, Orji, E., Adanikin, P.O. and Olaniyan, O. (2014) Comparative study of rectal misoprostol to oxytocin infusion in preventing postpartum haemorrhage after caesarean section. Nepal Journal of Obstetrics and Gynaecology, 8 (16), 34-37. (doi:10.3126/njog.v8i2.9767).

Record type: Article

Abstract

Aims: This comparative study aimed to compare the efficacy of rectal misoprostol to oxytocin infusion in preventing primary postpartum haemorrhage after caesarean section.

Methods: Fifty pregnant women with identifiable risk factors for post-partum haemorrhage who delivered baby by caesarean section were randomized to receive 600 ?g rectal misoprostol and a placebo infusion intravenously or placebo rectally and a 20 iu oxytocin infusion. Post-operative blood loss four hours after surgery was estimated by application of pads of known weight.

Results: The mean immediate four hours post-operative blood loss was not significantly different between the rectal misoprostol and oxytocin infusion group (100.08 ± 24.85 ml versus 108.20 ± 29.93 ml; p =0.144) and the change between the pre-operative and post-operative hematocrit was similar.

Conclusions: Post-caesarean section rectal misoprostol has comparative efficacy to oxytocin infusion in preventing post-partum haemorrhage. It is recommended for use as alternative uterotonic in settings where there is low refrigeration capacity.

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More information

e-pub ahead of print date: December 2013
Published date: June 2014
Keywords: caesarean section, misoprostol, oxytocin infusion, postpartum haemorrhage
Organisations: Social Statistics & Demography

Identifiers

Local EPrints ID: 396651
URI: http://eprints.soton.ac.uk/id/eprint/396651
ISSN: 1999-9623
PURE UUID: 9a40137f-9a24-40d2-8367-0db2952aae3b

Catalogue record

Date deposited: 09 Jun 2016 13:32
Last modified: 09 Nov 2021 04:47

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Contributors

Author: Abiodun, Idowu Adanikin
Author: E. Orji
Author: P.O. Adanikin
Author: O. Olaniyan

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