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Outcome reporting in randomized controlled trials and systematic reviews of gastroschisis treatment: a systematic review

Outcome reporting in randomized controlled trials and systematic reviews of gastroschisis treatment: a systematic review
Outcome reporting in randomized controlled trials and systematic reviews of gastroschisis treatment: a systematic review
Background

Core outcome sets (COS) facilitate clinical research by providing an agreed set of outcomes to be measured when evaluating treatment efficacy. Gastroschisis is increasing in frequency and evidence-based treatments are lacking. We aimed to identify initial candidate outcomes for a gastroschisis COS from existing literature.

Methods

Using a sensitive search strategy we identified randomized controlled trials (RCTs) and systematic reviews (SRs) of treatment interventions for gastroschisis. Outcomes were extracted and assigned to the core areas, ‘Pathophysiological Manifestations’, ‘Life Impact’, ‘Resource Use’, ‘Adverse Events’ and ‘Mortality’.

Results

A total of 50 outcomes were identified. RCTs reported 6–9 outcomes each; SRs reported 9–25. The most frequently reported outcomes were ‘Length of hospital stay’ (reported in 8 studies), ‘Duration of ventilation’ and ‘Time to full enteral feeds’ (7 studies). Outcomes identified could be assigned to all five core areas.

Conclusions

There is wide heterogeneity in outcomes reported in studies evaluating treatment interventions for gastroschisis. It is unclear which outcomes are of highest importance across stakeholder groups. Developing a COS to standardize outcome measurement and reporting for gastroschisis is warranted.
0022-3468
1385-1389
Ross, Andrew R.
84f7078f-8f5f-43a0-828a-7d791fcbdf52
Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf
Ross, Andrew R.
84f7078f-8f5f-43a0-828a-7d791fcbdf52
Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf

Ross, Andrew R. and Hall, Nigel J. (2016) Outcome reporting in randomized controlled trials and systematic reviews of gastroschisis treatment: a systematic review. Journal of Pediatric Surgery, 51 (8), 1385-1389. (doi:10.1016/j.jpedsurg.2016.05.008). (PMID:27312236)

Record type: Article

Abstract

Background

Core outcome sets (COS) facilitate clinical research by providing an agreed set of outcomes to be measured when evaluating treatment efficacy. Gastroschisis is increasing in frequency and evidence-based treatments are lacking. We aimed to identify initial candidate outcomes for a gastroschisis COS from existing literature.

Methods

Using a sensitive search strategy we identified randomized controlled trials (RCTs) and systematic reviews (SRs) of treatment interventions for gastroschisis. Outcomes were extracted and assigned to the core areas, ‘Pathophysiological Manifestations’, ‘Life Impact’, ‘Resource Use’, ‘Adverse Events’ and ‘Mortality’.

Results

A total of 50 outcomes were identified. RCTs reported 6–9 outcomes each; SRs reported 9–25. The most frequently reported outcomes were ‘Length of hospital stay’ (reported in 8 studies), ‘Duration of ventilation’ and ‘Time to full enteral feeds’ (7 studies). Outcomes identified could be assigned to all five core areas.

Conclusions

There is wide heterogeneity in outcomes reported in studies evaluating treatment interventions for gastroschisis. It is unclear which outcomes are of highest importance across stakeholder groups. Developing a COS to standardize outcome measurement and reporting for gastroschisis is warranted.

Text
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More information

Submitted date: 3 December 2015
Accepted/In Press date: 17 May 2016
e-pub ahead of print date: 31 May 2016
Published date: August 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 396705
URI: http://eprints.soton.ac.uk/id/eprint/396705
ISSN: 0022-3468
PURE UUID: f8da7ace-8226-4269-ba0f-f6995cbd2b49
ORCID for Nigel J. Hall: ORCID iD orcid.org/0000-0001-8570-9374

Catalogue record

Date deposited: 13 Jun 2016 14:18
Last modified: 07 Oct 2020 04:56

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