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The importance of the film structure during self-powered Ibuprofen salicylate drug release from polypyrrole electrodeposited on AZ31 Mg

The importance of the film structure during self-powered Ibuprofen salicylate drug release from polypyrrole electrodeposited on AZ31 Mg
The importance of the film structure during self-powered Ibuprofen salicylate drug release from polypyrrole electrodeposited on AZ31 Mg
Therapeutic drugs uploaded into conjugated conductive polymer matrices deposited on active magnesium alloys serve as controlled dose, self-powered drug delivery systems. Preferentially drugs are added into polymer films in the largest amount possible, mostly to prevent long-term treatments. However, added drugs might interact with the polymer matrix affecting either the structure or the final mechanical properties of the polymer film. In this work polypyrrole films (PPy) electrodeposited on an AZ31 Mg alloy in ibuprofen and salicylate containing solutions are investigated in terms of their uploading capacity, surface morphology and mechanical properties. The techniques used to investigate the uploaded PPy films include cyclic voltammetry (CV), SEM, EDS and depth-sensing indentation (DSI). A maximum ibuprofen concentration of 440±40 µg cm-2 was obtained in PPy films in the presence of sodium salicylate. The release fraction of ibuprofen as a function of time is fitted to Avrami’s equation. The hardness and reduced modulus decreased by 54% and 40% respectively, when the Ppy films are prepared in the presence of sodium ibuprofen compared with those prepared in sodium salicylate only, indicating a more plastic film with ibuprofen.
1432-8488
3375-3382
Alshammary, Badr
e32e4e92-e5d5-4135-8655-7e287bf81759
Casillas, Norberto
39ced5c0-db14-4439-9615-07627a385252
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Swingler, Jonathan
c6e2a49e-fadd-4f38-99f7-0ee1e2c92fac
Ponce De Leon Albarran, Carlos
508a312e-75ff-4bcb-9151-dacc424d755c
Walsh, Frank
309528e7-062e-439b-af40-9309bc91efb2
Alshammary, Badr
e32e4e92-e5d5-4135-8655-7e287bf81759
Casillas, Norberto
39ced5c0-db14-4439-9615-07627a385252
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Swingler, Jonathan
c6e2a49e-fadd-4f38-99f7-0ee1e2c92fac
Ponce De Leon Albarran, Carlos
508a312e-75ff-4bcb-9151-dacc424d755c
Walsh, Frank
309528e7-062e-439b-af40-9309bc91efb2

Alshammary, Badr, Casillas, Norberto, Cook, Richard, Swingler, Jonathan, Ponce De Leon Albarran, Carlos and Walsh, Frank (2016) The importance of the film structure during self-powered Ibuprofen salicylate drug release from polypyrrole electrodeposited on AZ31 Mg. Journal of Solid State Electrochemistry, 20 (12), 3375-3382. (doi:10.1007/s10008-016-3288-2).

Record type: Article

Abstract

Therapeutic drugs uploaded into conjugated conductive polymer matrices deposited on active magnesium alloys serve as controlled dose, self-powered drug delivery systems. Preferentially drugs are added into polymer films in the largest amount possible, mostly to prevent long-term treatments. However, added drugs might interact with the polymer matrix affecting either the structure or the final mechanical properties of the polymer film. In this work polypyrrole films (PPy) electrodeposited on an AZ31 Mg alloy in ibuprofen and salicylate containing solutions are investigated in terms of their uploading capacity, surface morphology and mechanical properties. The techniques used to investigate the uploaded PPy films include cyclic voltammetry (CV), SEM, EDS and depth-sensing indentation (DSI). A maximum ibuprofen concentration of 440±40 µg cm-2 was obtained in PPy films in the presence of sodium salicylate. The release fraction of ibuprofen as a function of time is fitted to Avrami’s equation. The hardness and reduced modulus decreased by 54% and 40% respectively, when the Ppy films are prepared in the presence of sodium ibuprofen compared with those prepared in sodium salicylate only, indicating a more plastic film with ibuprofen.

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Accepted/In Press date: 9 June 2016
e-pub ahead of print date: 5 July 2016
Published date: December 2016
Organisations: Energy Technology Group

Identifiers

Local EPrints ID: 396733
URI: http://eprints.soton.ac.uk/id/eprint/396733
ISSN: 1432-8488
PURE UUID: f6732b00-056f-4905-ba64-1f3ea9dc74fb
ORCID for Carlos Ponce De Leon Albarran: ORCID iD orcid.org/0000-0002-1907-5913

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Date deposited: 13 Jun 2016 14:27
Last modified: 17 Dec 2019 06:46

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Contributors

Author: Badr Alshammary
Author: Norberto Casillas
Author: Richard Cook
Author: Jonathan Swingler
Author: Frank Walsh

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