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Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents

Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents
Ophthalmic herpes simplex viral keratitis (HSVK) is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study (HEDS) has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different HSVK disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.
1442-6404
1-38
Tsatsos, Michael
316badcf-46fc-4ba4-9fef-4d2fde02e50b
MacGregor, Cheryl
80ed5800-724d-442e-baca-4d84a5c87b45
Athanasiadis, Ioannis
f897abd7-694e-4840-b165-334b4ad80b69
Moschos, Marilita M.
e2681fdf-a8a4-40c9-89a2-c32eb739c4a3
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
Anderson, David
602602f5-f986-42db-b0e0-dfef3205cf80
Tsatsos, Michael
316badcf-46fc-4ba4-9fef-4d2fde02e50b
MacGregor, Cheryl
80ed5800-724d-442e-baca-4d84a5c87b45
Athanasiadis, Ioannis
f897abd7-694e-4840-b165-334b4ad80b69
Moschos, Marilita M.
e2681fdf-a8a4-40c9-89a2-c32eb739c4a3
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
Anderson, David
602602f5-f986-42db-b0e0-dfef3205cf80

Tsatsos, Michael, MacGregor, Cheryl, Athanasiadis, Ioannis, Moschos, Marilita M., Hossain, Parwez and Anderson, David (2016) Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. Clinical & Experimental Ophthalmology, 1-38. (doi:10.1111/ceo.12785). (PMID:27273328)

Record type: Article

Abstract

Ophthalmic herpes simplex viral keratitis (HSVK) is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study (HEDS) has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different HSVK disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.

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Accepted/In Press date: 25 May 2016
e-pub ahead of print date: 8 June 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 396746
URI: https://eprints.soton.ac.uk/id/eprint/396746
ISSN: 1442-6404
PURE UUID: a002f259-2e25-44a2-99b9-370de9674177
ORCID for Parwez Hossain: ORCID iD orcid.org/0000-0002-3131-2395

Catalogue record

Date deposited: 13 Jun 2016 14:39
Last modified: 03 Dec 2019 06:40

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