Herpes simplex virus keratitis: an update of the pathogenesisand current treatment with oral and topical antiviral agents
Herpes simplex virus keratitis: an update of the pathogenesisand current treatment with oral and topical antiviral agents
Ophthalmic herpes simplex viral keratitis (HSVK) is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study (HEDS) has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different HSVK disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.
1-38
Tsatsos, Michael
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MacGregor, Cheryl
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Athanasiadis, Ioannis
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Moschos, Marilita M.
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Hossain, Parwez
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Anderson, David
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Tsatsos, Michael
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MacGregor, Cheryl
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Athanasiadis, Ioannis
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Moschos, Marilita M.
e2681fdf-a8a4-40c9-89a2-c32eb739c4a3
Hossain, Parwez
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Anderson, David
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Tsatsos, Michael, MacGregor, Cheryl, Athanasiadis, Ioannis, Moschos, Marilita M., Hossain, Parwez and Anderson, David
(2016)
Herpes simplex virus keratitis: an update of the pathogenesisand current treatment with oral and topical antiviral agents.
Clinical & Experimental Ophthalmology, .
(doi:10.1111/ceo.12785).
(PMID:27273328)
Abstract
Ophthalmic herpes simplex viral keratitis (HSVK) is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study (HEDS) has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different HSVK disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.
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ceo12785PNH.pdf
- Accepted Manuscript
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Accepted/In Press date: 25 May 2016
e-pub ahead of print date: 8 June 2016
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 396746
URI: http://eprints.soton.ac.uk/id/eprint/396746
ISSN: 1442-6404
PURE UUID: a002f259-2e25-44a2-99b9-370de9674177
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Date deposited: 13 Jun 2016 14:39
Last modified: 15 Mar 2024 05:39
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Contributors
Author:
Michael Tsatsos
Author:
Cheryl MacGregor
Author:
Ioannis Athanasiadis
Author:
Marilita M. Moschos
Author:
David Anderson
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