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The effect of post-cesarean rectal misoprostol on intestinal motility

The effect of post-cesarean rectal misoprostol on intestinal motility
The effect of post-cesarean rectal misoprostol on intestinal motility
OBJECTIVE:

To determine whether rectally administered misoprostol can induce intestinal motility compared with oxytocin infusion when used to prevent primary postpartum hemorrhage after cesarean delivery.
METHODS:

In a prospective randomized double-blind study in Nigeria, 218 parturients undergoing cesarean delivery who had risk factors for primary postpartum hemorrhage were enrolled between July 1, 2010, and March 31, 2011. Participants received 600 ?g of rectal misoprostol or 20 intravenous units of oxytocin for 4 hours after surgery. The primary outcome was time until passage of flatus. Adverse effects, need for additional analgesic, and length of hospital stay were also assessed.
RESULTS:

The misoprostol group had a significantly shorter mean postoperative interval to passage of flatus (20.27 ± 7.77 hours versus 38.34 ± 10.98 hours; P<0.001) and commencement of regular diet (21.08 ± 7.69 hours versus 39.13 ± 10.94 hours; P<0.001). Gastrointestinal adverse effects were more frequent, albeit not significantly, in the misoprostol group: nausea, 6.4% versus 1.8%; vomiting, 7.3% versus 2.8%; and abdominal distension, 3.7% versus 2.8%. The need for additional analgesic was the same in the 2 groups.
CONCLUSION:

After cesarean delivery, rectal misoprostol had the added benefit of inducing intestinal motility. Misoprostol might be considered in a clinical setting where postoperative ileus is anticipated.
0020-7292
159-162
Adanikin, Abiodun, Idowu
7c475e5b-223b-4d26-9b60-85b32af15727
Orji, Ernest O.
12d4d8d9-8884-456b-a7d9-13ba23c2ea72
Fasubaa, Olusola B.
49b04e45-bded-475f-803e-dc7d51143eaa
Onwudiegwu, Uche
c6670f47-5b59-40eb-a797-d574ca33ee8c
Ijarotimi, Omotade A.
f8e3dc4c-f8ab-4237-89e2-fb6379bfb0d5
Olaniyan, Oluwaseyi
1496cf8f-c000-48ff-af21-55a0df3cae80
Adanikin, Abiodun, Idowu
7c475e5b-223b-4d26-9b60-85b32af15727
Orji, Ernest O.
12d4d8d9-8884-456b-a7d9-13ba23c2ea72
Fasubaa, Olusola B.
49b04e45-bded-475f-803e-dc7d51143eaa
Onwudiegwu, Uche
c6670f47-5b59-40eb-a797-d574ca33ee8c
Ijarotimi, Omotade A.
f8e3dc4c-f8ab-4237-89e2-fb6379bfb0d5
Olaniyan, Oluwaseyi
1496cf8f-c000-48ff-af21-55a0df3cae80

Adanikin, Abiodun, Idowu, Orji, Ernest O., Fasubaa, Olusola B., Onwudiegwu, Uche, Ijarotimi, Omotade A. and Olaniyan, Oluwaseyi (2012) The effect of post-cesarean rectal misoprostol on intestinal motility. International Journal of Gynecology & Obstetrics, 119 (2), 159-162. (doi:10.1016/j.ijgo.2012.05.033).

Record type: Article

Abstract

OBJECTIVE:

To determine whether rectally administered misoprostol can induce intestinal motility compared with oxytocin infusion when used to prevent primary postpartum hemorrhage after cesarean delivery.
METHODS:

In a prospective randomized double-blind study in Nigeria, 218 parturients undergoing cesarean delivery who had risk factors for primary postpartum hemorrhage were enrolled between July 1, 2010, and March 31, 2011. Participants received 600 ?g of rectal misoprostol or 20 intravenous units of oxytocin for 4 hours after surgery. The primary outcome was time until passage of flatus. Adverse effects, need for additional analgesic, and length of hospital stay were also assessed.
RESULTS:

The misoprostol group had a significantly shorter mean postoperative interval to passage of flatus (20.27 ± 7.77 hours versus 38.34 ± 10.98 hours; P<0.001) and commencement of regular diet (21.08 ± 7.69 hours versus 39.13 ± 10.94 hours; P<0.001). Gastrointestinal adverse effects were more frequent, albeit not significantly, in the misoprostol group: nausea, 6.4% versus 1.8%; vomiting, 7.3% versus 2.8%; and abdominal distension, 3.7% versus 2.8%. The need for additional analgesic was the same in the 2 groups.
CONCLUSION:

After cesarean delivery, rectal misoprostol had the added benefit of inducing intestinal motility. Misoprostol might be considered in a clinical setting where postoperative ileus is anticipated.

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More information

Published date: 2012
Organisations: Social Statistics & Demography

Identifiers

Local EPrints ID: 396921
URI: https://eprints.soton.ac.uk/id/eprint/396921
ISSN: 0020-7292
PURE UUID: bc55cbd2-fcca-41f7-8cec-b6395bc92f56

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Date deposited: 15 Jun 2016 14:09
Last modified: 15 Jul 2019 20:21

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