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An exploration of pharmacological and psychological interventions in patients with treatment-resistant affective disorders

An exploration of pharmacological and psychological interventions in patients with treatment-resistant affective disorders
An exploration of pharmacological and psychological interventions in patients with treatment-resistant affective disorders
Preface:
The Mood and Anxiety Disorder Service in Southampton is a regional specialist
service for patients with complex and usually treatment-resistant affective disorders, which accepts referrals mainly from secondary care mental health services. Professor David Baldwin is the lead consultant for this service. He has clinical and research expertise in the identification, assessment and treatment of depressive illness and anxiety disorders, and is the lead author of evidence-based treatment guidelines for anxiety disorders.
I have worked with Professor David Baldwin since 2008. Through his encouragement and support, I have undertaken a series of pharmacological and psychological interventions in patients with treatment-resistant affective disorders. My dual aims were to examine treatment recommendations within the Service, and to investigate the potential feasibility, effectiveness, and acceptability of non-pharmacological treatment options for groups of patients with severe treatment-resistant depression or generalised anxiety disorder (GAD): partly in the hope that this might inform the development of additional treatment interventions within the local services.
Inspection of the medical records of patients referred to the tertiary services in
Southampton allowed an examination of currently offered pharmacological and psychological treatments. I realized that for most patients, and often over long periods of treatment in secondary care mental health services, there had been a lack of non-pharmacological treatments options apart from cognitive behaviour therapy (CBT). This thesis includes a description of patients referred to the Service, including their demographic and clinical characteristics, and current and recommended treatments: and an account of the effectiveness and acceptability of two non-pharmacological group interventions, namely mindfulness-based CBT in patients with highly recurrent unipolar depressive disorder, and Yogic breathing in patients with treatment resistant GA.
Tiwari, Nupur
38fa5742-e04c-4f06-9ae1-a27fbccf5975
Tiwari, Nupur
38fa5742-e04c-4f06-9ae1-a27fbccf5975
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Garner, Matthew
3221c5b3-b951-4fec-b456-ec449e4ce072

Tiwari, Nupur (2015) An exploration of pharmacological and psychological interventions in patients with treatment-resistant affective disorders. University of Southampton, Faculty of Medicine, Doctoral Thesis, 257pp.

Record type: Thesis (Doctoral)

Abstract

Preface:
The Mood and Anxiety Disorder Service in Southampton is a regional specialist
service for patients with complex and usually treatment-resistant affective disorders, which accepts referrals mainly from secondary care mental health services. Professor David Baldwin is the lead consultant for this service. He has clinical and research expertise in the identification, assessment and treatment of depressive illness and anxiety disorders, and is the lead author of evidence-based treatment guidelines for anxiety disorders.
I have worked with Professor David Baldwin since 2008. Through his encouragement and support, I have undertaken a series of pharmacological and psychological interventions in patients with treatment-resistant affective disorders. My dual aims were to examine treatment recommendations within the Service, and to investigate the potential feasibility, effectiveness, and acceptability of non-pharmacological treatment options for groups of patients with severe treatment-resistant depression or generalised anxiety disorder (GAD): partly in the hope that this might inform the development of additional treatment interventions within the local services.
Inspection of the medical records of patients referred to the tertiary services in
Southampton allowed an examination of currently offered pharmacological and psychological treatments. I realized that for most patients, and often over long periods of treatment in secondary care mental health services, there had been a lack of non-pharmacological treatments options apart from cognitive behaviour therapy (CBT). This thesis includes a description of patients referred to the Service, including their demographic and clinical characteristics, and current and recommended treatments: and an account of the effectiveness and acceptability of two non-pharmacological group interventions, namely mindfulness-based CBT in patients with highly recurrent unipolar depressive disorder, and Yogic breathing in patients with treatment resistant GA.

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DM Thesis- Dr Nupur Tiwari.pdf - Other
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More information

Published date: December 2015
Organisations: University of Southampton, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 397645
URI: http://eprints.soton.ac.uk/id/eprint/397645
PURE UUID: ed3195c0-595b-4cb1-9086-06f35aa72df8
ORCID for David Baldwin: ORCID iD orcid.org/0000-0003-3343-0907
ORCID for Matthew Garner: ORCID iD orcid.org/0000-0001-9481-2226

Catalogue record

Date deposited: 11 Jul 2016 13:55
Last modified: 15 Mar 2024 03:12

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Contributors

Author: Nupur Tiwari
Thesis advisor: David Baldwin ORCID iD
Thesis advisor: Matthew Garner ORCID iD

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