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Visualized exploratory spatiotemporal analysis of hand-foot-mouth disease in southern China

Visualized exploratory spatiotemporal analysis of hand-foot-mouth disease in southern China
Visualized exploratory spatiotemporal analysis of hand-foot-mouth disease in southern China
Objectives: In epidemiological research, major studies have focused on theoretical models; however, few methods of visual analysis have been used to display the patterns of disease distribution.

Design: For this study, a method combining the space-time cube (STC) with space-time scan statistics (STSS) was used to analyze the pattern of incidence of hand-foot-mouth disease (HFMD) in Guangdong Province from May 2008 to March 2009. In this research, STC was used to display the spatiotemporal pattern of incidence of HFMD, and STSS were used to detect the local aggregations of the disease.

Setting: The hand-foot-mouth disease data were obtained from Guangdong Province from May 2008 to March 2009, with a total of 68,130 cases.

Results: The STC analysis revealed a differential pattern of HFMD incidence among different months and cities and also showed that the population density and average precipitation are correlated with the incidence of HFMD. The STSS analysis revealed that the most likely aggregation includes the Shenzhen, Foshan and Dongguan populations, which are the most developed regions in Guangdong Province.

Conclusion: Both STC and STSS are efficient tools for the exploratory data analysis of disease transmission. STC clearly displays the spatiotemporal patterns of disease. Using the maximum likelihood ratio, the STSS model precisely locates the most likely aggregation.
1932-6203
1-17
Huang, Ji-Xia
7f2b4d04-ece0-402f-8c47-7196e915a740
Wang, Jin-Feng
b8ccd997-188b-4d55-af4b-02f6189625ba
Li, Zhong-Jie
c6c1bcc6-e23f-4b30-bc15-ce18abbab914
Wang, Yan
2240068a-12e7-4ebb-9f2b-e1236d83ea5e
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Yang, Wei-Zhong
35daea8e-8d21-43ec-bc93-f39c1c304316
Huang, Ji-Xia
7f2b4d04-ece0-402f-8c47-7196e915a740
Wang, Jin-Feng
b8ccd997-188b-4d55-af4b-02f6189625ba
Li, Zhong-Jie
c6c1bcc6-e23f-4b30-bc15-ce18abbab914
Wang, Yan
2240068a-12e7-4ebb-9f2b-e1236d83ea5e
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Yang, Wei-Zhong
35daea8e-8d21-43ec-bc93-f39c1c304316

Huang, Ji-Xia, Wang, Jin-Feng, Li, Zhong-Jie, Wang, Yan, Lai, Shengjie and Yang, Wei-Zhong (2015) Visualized exploratory spatiotemporal analysis of hand-foot-mouth disease in southern China. PLoS ONE, 10 (11), 1-17. (doi:10.1371/journal.pone.0143411). (PMID:21347303)

Record type: Article

Abstract

Objectives: In epidemiological research, major studies have focused on theoretical models; however, few methods of visual analysis have been used to display the patterns of disease distribution.

Design: For this study, a method combining the space-time cube (STC) with space-time scan statistics (STSS) was used to analyze the pattern of incidence of hand-foot-mouth disease (HFMD) in Guangdong Province from May 2008 to March 2009. In this research, STC was used to display the spatiotemporal pattern of incidence of HFMD, and STSS were used to detect the local aggregations of the disease.

Setting: The hand-foot-mouth disease data were obtained from Guangdong Province from May 2008 to March 2009, with a total of 68,130 cases.

Results: The STC analysis revealed a differential pattern of HFMD incidence among different months and cities and also showed that the population density and average precipitation are correlated with the incidence of HFMD. The STSS analysis revealed that the most likely aggregation includes the Shenzhen, Foshan and Dongguan populations, which are the most developed regions in Guangdong Province.

Conclusion: Both STC and STSS are efficient tools for the exploratory data analysis of disease transmission. STC clearly displays the spatiotemporal patterns of disease. Using the maximum likelihood ratio, the STSS model precisely locates the most likely aggregation.

Other
Visualized Exploratory Spatiotemporal Analysis of Hand-Foot-Mouth Disease in Southern China_PLoS ONE2015.PDF - Version of Record
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 4 November 2015
Published date: 25 November 2015
Organisations: WorldPop, Population, Health & Wellbeing (PHeW)

Identifiers

Local EPrints ID: 398152
URI: http://eprints.soton.ac.uk/id/eprint/398152
ISSN: 1932-6203
PURE UUID: 46f586ae-fd2f-428c-904e-e6fc181dc071
ORCID for Shengjie Lai: ORCID iD orcid.org/0000-0001-9781-8148

Catalogue record

Date deposited: 20 Jul 2016 10:46
Last modified: 15 Mar 2024 04:02

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Contributors

Author: Ji-Xia Huang
Author: Jin-Feng Wang
Author: Zhong-Jie Li
Author: Yan Wang
Author: Shengjie Lai ORCID iD
Author: Wei-Zhong Yang

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