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Clinical usefulness of bone turnover marker concentrations in osteoporosis

Clinical usefulness of bone turnover marker concentrations in osteoporosis
Clinical usefulness of bone turnover marker concentrations in osteoporosis
Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the limitations identified earlier remain, principally in regard to the relationship between BTM and incident fractures. Important data are now available on reference interval values for CTX and PINP across a range of geographic regions and for individual clinical assays. An apparent lack of comparability between current clinical assays for CTX has become evident indicating the possible limitations of combining such data for meta-analyses. Harmonization of units for reporting serum/plasma CTX (ng/L) and PINP (?g/L) is recommended. The development of international collaborations continues with an important initiative to combine BTM results from clinical trials in osteoporosis in a meta-analysis and an assay harmonization program are likely to be beneficial. It is possible that knowledge derived from clinical studies can further enhance fracture risk estimation tools with inclusion of BTM together with other independent risk factors. Further data of the relationships between the clinical assays for CTX and PINP as well as physiological and pre-analytical factors contributing to variability in BTM concentrations are required.
Bone turnover markers, Osteoporosis, fracture risk, Reference intervals, Monitoring efficacy for treatment of osteoporosis, CTX, PINP
0009-8981
Morris, H.A.
43a0e3e8-d30f-479f-81dc-bd9e9166cca2
Eastell, R.
1650872d-d27d-4543-a112-d6008810fa25
Jorgesen, N.R.
56b9c81c-e039-4b00-9d33-8fa44ff51056
Cavalier, E.
f18d781a-5a9d-466c-8e80-c611adce0f97
Vasikaran, S.
3eba71cd-6b5a-4e05-a65e-42fcc2950507
Chubb, S.A.
e511f426-1d36-4632-9fbb-3bd23f8a7288
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Markis, K.
9bc9110e-663a-483b-af56-c59b04df4cf3
Morris, H.A.
43a0e3e8-d30f-479f-81dc-bd9e9166cca2
Eastell, R.
1650872d-d27d-4543-a112-d6008810fa25
Jorgesen, N.R.
56b9c81c-e039-4b00-9d33-8fa44ff51056
Cavalier, E.
f18d781a-5a9d-466c-8e80-c611adce0f97
Vasikaran, S.
3eba71cd-6b5a-4e05-a65e-42fcc2950507
Chubb, S.A.
e511f426-1d36-4632-9fbb-3bd23f8a7288
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Markis, K.
9bc9110e-663a-483b-af56-c59b04df4cf3

Morris, H.A., Eastell, R., Jorgesen, N.R., Cavalier, E., Vasikaran, S., Chubb, S.A., Kanis, J.A., Cooper, Cyrus and Markis, K. (2016) Clinical usefulness of bone turnover marker concentrations in osteoporosis. Clinica Chimica Acta. (doi:10.1016/j.cca.2016.06.036). (PMID:27374301)

Record type: Article

Abstract

Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the limitations identified earlier remain, principally in regard to the relationship between BTM and incident fractures. Important data are now available on reference interval values for CTX and PINP across a range of geographic regions and for individual clinical assays. An apparent lack of comparability between current clinical assays for CTX has become evident indicating the possible limitations of combining such data for meta-analyses. Harmonization of units for reporting serum/plasma CTX (ng/L) and PINP (?g/L) is recommended. The development of international collaborations continues with an important initiative to combine BTM results from clinical trials in osteoporosis in a meta-analysis and an assay harmonization program are likely to be beneficial. It is possible that knowledge derived from clinical studies can further enhance fracture risk estimation tools with inclusion of BTM together with other independent risk factors. Further data of the relationships between the clinical assays for CTX and PINP as well as physiological and pre-analytical factors contributing to variability in BTM concentrations are required.

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More information

Accepted/In Press date: 28 June 2016
e-pub ahead of print date: 30 June 2016
Keywords: Bone turnover markers, Osteoporosis, fracture risk, Reference intervals, Monitoring efficacy for treatment of osteoporosis, CTX, PINP
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 398155
URI: http://eprints.soton.ac.uk/id/eprint/398155
ISSN: 0009-8981
PURE UUID: 9b0fea4f-33bd-4654-a984-453408c349d2
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 19 Jul 2016 16:27
Last modified: 07 Oct 2020 01:40

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Contributors

Author: H.A. Morris
Author: R. Eastell
Author: N.R. Jorgesen
Author: E. Cavalier
Author: S. Vasikaran
Author: S.A. Chubb
Author: J.A. Kanis
Author: Cyrus Cooper ORCID iD
Author: K. Markis

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