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Editorial. Lung macrophages: old hands required rather than new blood?

Editorial. Lung macrophages: old hands required rather than new blood?
Editorial. Lung macrophages: old hands required rather than new blood?
Macrophages are key sentinel cells of the lung, clearing inhaled particulates and micro-organisms from the airway. These cells perform this function without provoking inflammatory responses that could lead to pneumonias. Previous work suggested that the lung macrophage population was maintained by the recruitment of blood monocytes. However, this observation was made in transplanted lungs where macrophages had been depleted, either by hypoxia or chemotherapy. More recent work in murine models using cell fate mapping demonstrated that lung macrophages are generated early in embryonic development initially in the foetal yolk sac and slightly later in the foetal liver. Macrophages that arise from these sources then seed the lung, where they reside as a self-renewing population with little further recruitment from blood monocytes.
0040-6376
973-974
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee

Staples, Karl J. (2016) Editorial. Lung macrophages: old hands required rather than new blood? Thorax, 71 (11), 973-974. (doi:10.1136/thoraxjnl-2016-208992). (PMID:27531530)

Record type: Editorial

Abstract

Macrophages are key sentinel cells of the lung, clearing inhaled particulates and micro-organisms from the airway. These cells perform this function without provoking inflammatory responses that could lead to pneumonias. Previous work suggested that the lung macrophage population was maintained by the recruitment of blood monocytes. However, this observation was made in transplanted lungs where macrophages had been depleted, either by hypoxia or chemotherapy. More recent work in murine models using cell fate mapping demonstrated that lung macrophages are generated early in embryonic development initially in the foetal yolk sac and slightly later in the foetal liver. Macrophages that arise from these sources then seed the lung, where they reside as a self-renewing population with little further recruitment from blood monocytes.

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Thorax editorial_Staples Macrophage editorial 2016-07-25.doc - Accepted Manuscript
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More information

Accepted/In Press date: 25 July 2016
e-pub ahead of print date: 16 August 2016
Published date: November 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 398533
URI: https://eprints.soton.ac.uk/id/eprint/398533
ISSN: 0040-6376
PURE UUID: ee049e8d-db4e-495f-b205-72432d677f21
ORCID for Karl J. Staples: ORCID iD orcid.org/0000-0003-3844-6457

Catalogue record

Date deposited: 26 Jul 2016 09:30
Last modified: 10 Aug 2019 04:01

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