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Temporal changes in chromosome abnormalities in human spontaneous abortions: results of 40 years of analysis

Temporal changes in chromosome abnormalities in human spontaneous abortions: results of 40 years of analysis
Temporal changes in chromosome abnormalities in human spontaneous abortions: results of 40 years of analysis
Studies during the past 50 years demonstrate the importance of chromosome abnormalities to the occurrence of early pregnancy loss in humans. Intriguingly, there appears to be considerable variation in the rates of chromosome abnormality, with more recent studies typically reporting higher levels than those reported in early studies of spontaneous abortions. We were interested in examining the basis for these differences and accordingly, we reviewed studies of spontaneous abortions conducted in our laboratories over a 40-year-time span. Our analyses confirm a higher rate of abnormality in more recent series of spontaneous abortions, but indicate that the effect is largely, if not entirely, attributable to changes over time in the maternal age structures of the study populations
1552-4825
2671-2680
Hardy, Kathy
bb8f4d9d-9f22-4244-8666-cb838a6119f0
Hardy, Philip J.
720fc22b-0344-462a-be79-c15fc6daf93d
Jacobs, Patricia
11d48bfa-0a1d-47e6-8159-fe8835a84a2a
Lewallen, Kevin
dd0196fa-86f2-4d3c-bf9b-c814e9905d13
Hassold, Terry J.
93117e5b-0687-4fd2-9816-97c2972824a0
Hardy, Kathy
bb8f4d9d-9f22-4244-8666-cb838a6119f0
Hardy, Philip J.
720fc22b-0344-462a-be79-c15fc6daf93d
Jacobs, Patricia
11d48bfa-0a1d-47e6-8159-fe8835a84a2a
Lewallen, Kevin
dd0196fa-86f2-4d3c-bf9b-c814e9905d13
Hassold, Terry J.
93117e5b-0687-4fd2-9816-97c2972824a0

Hardy, Kathy, Hardy, Philip J., Jacobs, Patricia, Lewallen, Kevin and Hassold, Terry J. (2016) Temporal changes in chromosome abnormalities in human spontaneous abortions: results of 40 years of analysis. American Journal of Medical Genetics part A, 170 (10), 2671-2680. (doi:10.1002/ajmg.a.37795). (PMID:27287007)

Record type: Article

Abstract

Studies during the past 50 years demonstrate the importance of chromosome abnormalities to the occurrence of early pregnancy loss in humans. Intriguingly, there appears to be considerable variation in the rates of chromosome abnormality, with more recent studies typically reporting higher levels than those reported in early studies of spontaneous abortions. We were interested in examining the basis for these differences and accordingly, we reviewed studies of spontaneous abortions conducted in our laboratories over a 40-year-time span. Our analyses confirm a higher rate of abnormality in more recent series of spontaneous abortions, but indicate that the effect is largely, if not entirely, attributable to changes over time in the maternal age structures of the study populations

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More information

Accepted/In Press date: 31 May 2016
e-pub ahead of print date: 10 June 2016
Published date: October 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 398590
URI: http://eprints.soton.ac.uk/id/eprint/398590
ISSN: 1552-4825
PURE UUID: cdb6be3a-fdfd-4d98-a90f-98345ff7d813

Catalogue record

Date deposited: 29 Jul 2016 09:31
Last modified: 06 Oct 2020 18:00

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