Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients
Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients
Iron misregulation promotes oxidative stress, a proposed pathological mechanism in neurodegenerative disease. The aim of this study was to evaluate serum iron metabolism indicators in 60 amyotrophic lateral sclerosis (ALS) patients and 44 age matched controls. Serum ferritin levels were significantly increased in ALS patients compared to controls (p < 0.001), while no differences in the levels of serum iron, transferrin, iron saturation or total iron binding capacity were found. Likewise no differences in C reactive protein (CRP) or caeruloplasmin were detected, suggesting that the elevated ferritin levels in ALS did not merely indicate an acute phase response. The increased ferritin level may reflect a general increase in stored iron or be a consequence of ongoing muscle degeneration.
1652-1656
Goodall, E.F.
fab15975-65f1-4a33-a282-4e85bad0733d
Haque, M.S.
be33f510-9a3f-429d-beb3-2a09e7befffe
Morrison, K.E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
November 2008
Goodall, E.F.
fab15975-65f1-4a33-a282-4e85bad0733d
Haque, M.S.
be33f510-9a3f-429d-beb3-2a09e7befffe
Morrison, K.E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Goodall, E.F., Haque, M.S. and Morrison, K.E.
(2008)
Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients.
Journal of Neurology, 255 (11), .
(doi:10.1007/s00415-008-0945-0).
Abstract
Iron misregulation promotes oxidative stress, a proposed pathological mechanism in neurodegenerative disease. The aim of this study was to evaluate serum iron metabolism indicators in 60 amyotrophic lateral sclerosis (ALS) patients and 44 age matched controls. Serum ferritin levels were significantly increased in ALS patients compared to controls (p < 0.001), while no differences in the levels of serum iron, transferrin, iron saturation or total iron binding capacity were found. Likewise no differences in C reactive protein (CRP) or caeruloplasmin were detected, suggesting that the elevated ferritin levels in ALS did not merely indicate an acute phase response. The increased ferritin level may reflect a general increase in stored iron or be a consequence of ongoing muscle degeneration.
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Accepted/In Press date: 14 March 2008
e-pub ahead of print date: 18 July 2008
Published date: November 2008
Organisations:
Medical Education
Identifiers
Local EPrints ID: 398776
URI: http://eprints.soton.ac.uk/id/eprint/398776
ISSN: 0340-5354
PURE UUID: 412950fc-8f34-4712-8f23-90a861a5eef6
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Date deposited: 02 Aug 2016 10:22
Last modified: 15 Mar 2024 01:41
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Author:
E.F. Goodall
Author:
M.S. Haque
Author:
K.E. Morrison
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