Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis
Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis
There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case–control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.
1279-1282
Xiao, Shangxi
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Sato, Christine
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Kawarai, Toshitaka
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Goodall, Emily F.
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Pall, Hardev S.
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Zinman, Lorne H.
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Robertson, Janice
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Morrison, Karen
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Rogaeva, Ekaterina
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August 2008
Xiao, Shangxi
29f22f80-6f6d-433d-9416-55d2343c10a9
Sato, Christine
3ceee1d5-db2f-4c84-bdab-8aaaf573f07a
Kawarai, Toshitaka
a6cdaccf-c6d7-4257-bfb1-7263cda1b242
Goodall, Emily F.
b1af5241-f788-44b5-966c-510db4ca24ef
Pall, Hardev S.
270999ad-5e88-4485-b48b-d9b60858cfb1
Zinman, Lorne H.
b0acbd09-3f79-4603-ad36-ccdaf0dd696a
Robertson, Janice
591070e6-ba35-4e33-886e-a5f2b83a375c
Morrison, Karen
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Rogaeva, Ekaterina
f9d53d18-eb3d-44d5-add8-dc35f288f6dd
Xiao, Shangxi, Sato, Christine, Kawarai, Toshitaka, Goodall, Emily F., Pall, Hardev S., Zinman, Lorne H., Robertson, Janice, Morrison, Karen and Rogaeva, Ekaterina
(2008)
Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.
Neurobiology of Aging, 29 (8), .
(doi:10.1016/j.neurobiolaging.2007.02.022).
Abstract
There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case–control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.
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Accepted/In Press date: 10 February 2007
e-pub ahead of print date: 23 March 2007
Published date: August 2008
Organisations:
Medical Education
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Local EPrints ID: 398778
URI: http://eprints.soton.ac.uk/id/eprint/398778
PURE UUID: 6b7818df-83f7-4c32-99af-7df7a8217c7c
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Date deposited: 02 Aug 2016 10:29
Last modified: 15 Mar 2024 01:41
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Contributors
Author:
Shangxi Xiao
Author:
Christine Sato
Author:
Toshitaka Kawarai
Author:
Emily F. Goodall
Author:
Hardev S. Pall
Author:
Lorne H. Zinman
Author:
Janice Robertson
Author:
Karen Morrison
Author:
Ekaterina Rogaeva
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