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Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS

Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS
Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS
Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).
0028-3878
934-937
Goodall, E.F.
fab15975-65f1-4a33-a282-4e85bad0733d
Greenway, M.J.
0f3f497b-36f6-4faa-97b0-9aba3b69aa5c
van Marion, I.
d1662dd4-1342-4ac6-8611-7630b012f402
Carroll, C.B.
53eac18d-745e-450f-b425-a9c431d5fc4e
Hardiman, O.
eccbab7a-06c1-4271-b4f0-c420708109a7
Morrison, K.E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Goodall, E.F.
fab15975-65f1-4a33-a282-4e85bad0733d
Greenway, M.J.
0f3f497b-36f6-4faa-97b0-9aba3b69aa5c
van Marion, I.
d1662dd4-1342-4ac6-8611-7630b012f402
Carroll, C.B.
53eac18d-745e-450f-b425-a9c431d5fc4e
Hardiman, O.
eccbab7a-06c1-4271-b4f0-c420708109a7
Morrison, K.E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8

Goodall, E.F., Greenway, M.J., van Marion, I., Carroll, C.B., Hardiman, O. and Morrison, K.E. (2005) Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS. Neurology, 65 (6), 934-937. (doi:10.1212/01.wnl.0000176032.94434.d4).

Record type: Article

Abstract

Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).

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Published date: September 2005
Organisations: Medical Education

Identifiers

Local EPrints ID: 398839
URI: http://eprints.soton.ac.uk/id/eprint/398839
ISSN: 0028-3878
PURE UUID: f60749ba-d44d-407d-8933-b0e76e265aac
ORCID for K.E. Morrison: ORCID iD orcid.org/0000-0003-0216-5717

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Date deposited: 02 Aug 2016 12:23
Last modified: 10 Dec 2019 01:32

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Contributors

Author: E.F. Goodall
Author: M.J. Greenway
Author: I. van Marion
Author: C.B. Carroll
Author: O. Hardiman
Author: K.E. Morrison ORCID iD

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