Morrison, Karen E. (2002) Therapies in amyotrophic lateral sclerosis–beyond riluzole. Current Opinion in Pharmacology, 2 (3), 302-309. (doi:10.1016/S1471-4892(02)00169-8).
Abstract
Several mechanisms have been proposed to account for the progressive motor neurone death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament damage, mitochondrial abnormalities, glutamate-mediated excitotoxicity and altered responses to hypoxia. Current quests for therapies involve studying combinations of agents that act by various mechanisms and evaluating stem-cell therapies in model systems. High-throughput cell-culture screening systems are also being developed. The goal for therapy is to define agents that clearly prevent progression of, and it is hoped even reverse, motor neurone loss.
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