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Therapies in amyotrophic lateral sclerosis–beyond riluzole

Therapies in amyotrophic lateral sclerosis–beyond riluzole
Therapies in amyotrophic lateral sclerosis–beyond riluzole
Several mechanisms have been proposed to account for the progressive motor neurone death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament damage, mitochondrial abnormalities, glutamate-mediated excitotoxicity and altered responses to hypoxia. Current quests for therapies involve studying combinations of agents that act by various mechanisms and evaluating stem-cell therapies in model systems. High-throughput cell-culture screening systems are also being developed. The goal for therapy is to define agents that clearly prevent progression of, and it is hoped even reverse, motor neurone loss.
1471-4892
302-309
Morrison, Karen E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Morrison, Karen E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8

Morrison, Karen E. (2002) Therapies in amyotrophic lateral sclerosis–beyond riluzole. Current Opinion in Pharmacology, 2 (3), 302-309. (doi:10.1016/S1471-4892(02)00169-8).

Record type: Article

Abstract

Several mechanisms have been proposed to account for the progressive motor neurone death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament damage, mitochondrial abnormalities, glutamate-mediated excitotoxicity and altered responses to hypoxia. Current quests for therapies involve studying combinations of agents that act by various mechanisms and evaluating stem-cell therapies in model systems. High-throughput cell-culture screening systems are also being developed. The goal for therapy is to define agents that clearly prevent progression of, and it is hoped even reverse, motor neurone loss.

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More information

e-pub ahead of print date: 24 May 2002
Published date: June 2002
Organisations: Medical Education

Identifiers

Local EPrints ID: 398844
URI: http://eprints.soton.ac.uk/id/eprint/398844
ISSN: 1471-4892
PURE UUID: 952f7634-82a4-40d2-8975-c3cbb177b41f
ORCID for Karen E. Morrison: ORCID iD orcid.org/0000-0003-0216-5717

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Date deposited: 02 Aug 2016 12:47
Last modified: 15 Mar 2024 01:43

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Author: Karen E. Morrison ORCID iD

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