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Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study

Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study
Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study
Women with a history of preeclampsia have an increased risk for cardiovascular diseases later in life. Persistent vascular alterations in the postpartum period might contribute to this increased risk. The current study assessed arterial stiffness under low sodium (LS) and high sodium (HS) conditions in a well-characterized group of formerly early-onset preeclamptic (fPE) women and formerly pregnant (fHP) women. Eighteen fHP and 18 fPE women were studied at an average of 5 yr after pregnancy on 1 wk of LS (50 mmol Na(+)/day) and 1 wk of HS (200 mmol Na(+)/day) intake. Arterial stiffness was measured by pulse-wave analysis (aortic augmentation index, AIx) and carotid-femoral pulse-wave velocity (PWV). Circulating markers of the renin-angiotensin aldosterone system (RAAS), extracellular volume (ECV), nitric oxide (NO), and hydrogen sulfide (H2S) were measured in an effort to identify potential mechanistic elements underlying adaptation of arterial stiffness. AIx was significantly lower in fHP women on LS compared with HS while no difference in AIx was apparent in fPE women. PWV remained unchanged upon different sodium loads in either group. Comparable sodium-dependent changes in RAAS, ECV, and NO/H2S were observed in fHP and fPE women. fPE women have an impaired ability to adapt their arterial stiffness in response to changes in sodium intake, independently of blood pressure, RAAS, ECV, and NO/H2S status. The pathways involved in impaired adaptation of arterial stiffness, and its possible contribution to the increased long-term risk for cardiovascular diseases in fPE women, remain to be investigated.
0363-6135
H1827-H1833
van der Graaf, Anne Marijn
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Paauw, Nina D.
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Toering, Tsjitske J
9c442e69-46af-482e-b6d4-bf0e85f335e2
Feelisch, Martin
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Faas, Marijke M.
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Sutton, Thomas R.
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Minnion, Magdalena
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Lefrandt, Joop D.
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Scherjon, Sicco A.
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Franx, Arie
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Navis, Gerjan
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Lely, A. Titia
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van der Graaf, Anne Marijn
e7c326fb-077f-4c7c-90eb-3dc1a2c6d6bb
Paauw, Nina D.
c90d2be6-b2a8-454a-827d-c58fd518e7fe
Toering, Tsjitske J
9c442e69-46af-482e-b6d4-bf0e85f335e2
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Faas, Marijke M.
00ed765a-7ba4-4b2f-8dc9-6713282b6c43
Sutton, Thomas R.
b9cfebad-0058-44b0-8cdf-b253bd7de0a4
Minnion, Magdalena
611377b5-e523-4568-a172-68e81cecb432
Lefrandt, Joop D.
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Scherjon, Sicco A.
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Franx, Arie
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Navis, Gerjan
9f86f3c1-5e6e-49ab-97ff-261bb46a9900
Lely, A. Titia
0c34bf2f-7178-4c70-be7a-c64355d7f9e2

van der Graaf, Anne Marijn, Paauw, Nina D., Toering, Tsjitske J, Feelisch, Martin, Faas, Marijke M., Sutton, Thomas R., Minnion, Magdalena, Lefrandt, Joop D., Scherjon, Sicco A., Franx, Arie, Navis, Gerjan and Lely, A. Titia (2016) Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study. American Journal of Physiology: Heart and Circulatory Physiology, 310 (11), H1827-H1833. (doi:10.1152/ajpheart.00010.2016). (PMID:27059075)

Record type: Article

Abstract

Women with a history of preeclampsia have an increased risk for cardiovascular diseases later in life. Persistent vascular alterations in the postpartum period might contribute to this increased risk. The current study assessed arterial stiffness under low sodium (LS) and high sodium (HS) conditions in a well-characterized group of formerly early-onset preeclamptic (fPE) women and formerly pregnant (fHP) women. Eighteen fHP and 18 fPE women were studied at an average of 5 yr after pregnancy on 1 wk of LS (50 mmol Na(+)/day) and 1 wk of HS (200 mmol Na(+)/day) intake. Arterial stiffness was measured by pulse-wave analysis (aortic augmentation index, AIx) and carotid-femoral pulse-wave velocity (PWV). Circulating markers of the renin-angiotensin aldosterone system (RAAS), extracellular volume (ECV), nitric oxide (NO), and hydrogen sulfide (H2S) were measured in an effort to identify potential mechanistic elements underlying adaptation of arterial stiffness. AIx was significantly lower in fHP women on LS compared with HS while no difference in AIx was apparent in fPE women. PWV remained unchanged upon different sodium loads in either group. Comparable sodium-dependent changes in RAAS, ECV, and NO/H2S were observed in fHP and fPE women. fPE women have an impaired ability to adapt their arterial stiffness in response to changes in sodium intake, independently of blood pressure, RAAS, ECV, and NO/H2S status. The pathways involved in impaired adaptation of arterial stiffness, and its possible contribution to the increased long-term risk for cardiovascular diseases in fPE women, remain to be investigated.

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Accepted/In Press date: 6 April 2016
e-pub ahead of print date: 8 April 2016
Published date: 1 June 2016
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 399209
URI: https://eprints.soton.ac.uk/id/eprint/399209
ISSN: 0363-6135
PURE UUID: 5ad7e772-3540-4d57-a41d-07c5f2c987d6
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 09 Aug 2016 11:41
Last modified: 10 Dec 2019 06:27

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Contributors

Author: Anne Marijn van der Graaf
Author: Nina D. Paauw
Author: Tsjitske J Toering
Author: Martin Feelisch ORCID iD
Author: Marijke M. Faas
Author: Thomas R. Sutton
Author: Magdalena Minnion
Author: Joop D. Lefrandt
Author: Sicco A. Scherjon
Author: Arie Franx
Author: Gerjan Navis
Author: A. Titia Lely

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