The University of Southampton
University of Southampton Institutional Repository

A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications

A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications
A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications
The development of bulk, three-dimensional (3D), macroporous polymers with high permeability, large surface area and large volume is highly desirable for a range of applications in the biomedical, biotechnological and environmental areas. The experimental techniques currently used are limited to the production of small size and volume cryogel material. In this work we propose a novel, versatile, simple and reproducible method for the synthesis of large volume porous polymer hydrogels by cryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3D macroporous gels with wide interconnected pores (up to 200??m in diameter) and large accessible surface area have been synthesized. For the first time, macroporous gels (of up to 400?ml bulk volume) with controlled porous structure were manufactured, with potential for scale up to much larger gel dimensions. This method can be used for production of novel 3D multi-component macroporous composite materials with a uniform distribution of embedded particles. The proposed method provides better control of freezing conditions and thus overcomes existing drawbacks limiting production of large gel-based devices and matrices. The proposed method could serve as a new design concept for functional 3D macroporous gels and composites preparation for biomedical, biotechnological and environmental applications.
21154
Savina, Irina N.
5e5c7acd-71ef-4fb3-baaf-0b98fec91845
Ingavle, Ganesh C.
c8a00aa7-741d-4d95-94f1-d05c4d015175
Cundy, Andrew B.
994fdc96-2dce-40f4-b74b-dc638286eb08
Mikhalovsky, Sergey V.
069cc234-fe97-4055-97ed-5bec73bf8d0d
Savina, Irina N.
5e5c7acd-71ef-4fb3-baaf-0b98fec91845
Ingavle, Ganesh C.
c8a00aa7-741d-4d95-94f1-d05c4d015175
Cundy, Andrew B.
994fdc96-2dce-40f4-b74b-dc638286eb08
Mikhalovsky, Sergey V.
069cc234-fe97-4055-97ed-5bec73bf8d0d

Savina, Irina N., Ingavle, Ganesh C., Cundy, Andrew B. and Mikhalovsky, Sergey V. (2016) A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications. Scientific Reports, 6, 21154. (doi:10.1038/srep21154).

Record type: Article

Abstract

The development of bulk, three-dimensional (3D), macroporous polymers with high permeability, large surface area and large volume is highly desirable for a range of applications in the biomedical, biotechnological and environmental areas. The experimental techniques currently used are limited to the production of small size and volume cryogel material. In this work we propose a novel, versatile, simple and reproducible method for the synthesis of large volume porous polymer hydrogels by cryogelation. By controlling the freezing process of the reagent/polymer solution, large-scale 3D macroporous gels with wide interconnected pores (up to 200??m in diameter) and large accessible surface area have been synthesized. For the first time, macroporous gels (of up to 400?ml bulk volume) with controlled porous structure were manufactured, with potential for scale up to much larger gel dimensions. This method can be used for production of novel 3D multi-component macroporous composite materials with a uniform distribution of embedded particles. The proposed method provides better control of freezing conditions and thus overcomes existing drawbacks limiting production of large gel-based devices and matrices. The proposed method could serve as a new design concept for functional 3D macroporous gels and composites preparation for biomedical, biotechnological and environmental applications.

Text
srep21154.pdf - Version of Record
Available under License Creative Commons Attribution.
Download (1MB)

More information

Published date: 17 February 2016
Organisations: Geochemistry

Identifiers

Local EPrints ID: 399257
URI: https://eprints.soton.ac.uk/id/eprint/399257
PURE UUID: e37a590e-87fa-4113-8d85-abf9fb7972c8
ORCID for Andrew B. Cundy: ORCID iD orcid.org/0000-0003-4368-2569

Catalogue record

Date deposited: 09 Aug 2016 16:10
Last modified: 15 Aug 2019 00:32

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×