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Rapid treatment of subungual onychomycosis using controlled micro nail penetration and terbinafine solution

Rapid treatment of subungual onychomycosis using controlled micro nail penetration and terbinafine solution
Rapid treatment of subungual onychomycosis using controlled micro nail penetration and terbinafine solution
Onychomycosis continues to be a common and intractable problem in adults, often responding poorly to topical treatment due to limited drug penetration of the nail plate. Improving penetration has been attempted previously by chemical and physical means with some success. The authors present three cases of toenail onychomycosis treated topical terbinafine 1% solution using controlled micro-penetration of the nail using a novel intelligent nail drill system which is able to drill nail plate without penetrating the delicate nail bed beneath. The cases illustrate how the device has been successfully employed to deliver the anti-fungal drug directly and rapidly to the site of infection with minimal side effects or complications, whilst maintaining the nail integrity.
1545-9616
974-978
Bristow, Ivan
f1974879-83d4-4944-8c4b-dddc51e71a22
Baran, Robert
a753cb21-c5ad-41db-817b-f60248bbf4c9
Score, Michelle
e137ab00-327a-4e78-ab2e-842edf9f6ce1
Bristow, Ivan
f1974879-83d4-4944-8c4b-dddc51e71a22
Baran, Robert
a753cb21-c5ad-41db-817b-f60248bbf4c9
Score, Michelle
e137ab00-327a-4e78-ab2e-842edf9f6ce1

Bristow, Ivan, Baran, Robert and Score, Michelle (2016) Rapid treatment of subungual onychomycosis using controlled micro nail penetration and terbinafine solution. Journal of Drugs in Dermatology, 15 (8), 974-978. (PMID:27537998)

Record type: Article

Abstract

Onychomycosis continues to be a common and intractable problem in adults, often responding poorly to topical treatment due to limited drug penetration of the nail plate. Improving penetration has been attempted previously by chemical and physical means with some success. The authors present three cases of toenail onychomycosis treated topical terbinafine 1% solution using controlled micro-penetration of the nail using a novel intelligent nail drill system which is able to drill nail plate without penetrating the delicate nail bed beneath. The cases illustrate how the device has been successfully employed to deliver the anti-fungal drug directly and rapidly to the site of infection with minimal side effects or complications, whilst maintaining the nail integrity.

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Accepted/In Press date: 1 August 2016
Published date: August 2016
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 399450
URI: http://eprints.soton.ac.uk/id/eprint/399450
ISSN: 1545-9616
PURE UUID: 9c4d9065-80f1-4f38-8149-ece618e3f1b1

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Date deposited: 23 Aug 2016 12:45
Last modified: 16 Dec 2019 19:46

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