Alpha-3 chain type IV collagen polypeptides
Alpha-3 chain type IV collagen polypeptides
An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous domain of the bovine .alpha.3 chain of type IV collagen. An isolated and substantially pure polynucleotide encoding 218 amino acids of the carboxy terminal noncollagenous domain of the human .alpha.3 chain of type IV collagen. Such polynucleotides are useful to express large amounts of proteins in vectors and such expressed proteins are useful to detect Goodpasture antibodies in blood and to remove Goodpasture antibodies from the bloodstream of patients suffering from Goodpasture syndrome.
US6,007,980
28 December 1999
Reeders, Stephen T.
7a905a1a-d6de-49dd-a5be-ded5220fd725
Morrison, Karen E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Hudson, Billy G.
8d09869e-2eeb-4349-b3fd-2de782a77cda
Reeders, Stephen T., Morrison, Karen E. and Hudson, Billy G.
(Inventors)
(1999)
Alpha-3 chain type IV collagen polypeptides.
US6,007,980.
Abstract
An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous domain of the bovine .alpha.3 chain of type IV collagen. An isolated and substantially pure polynucleotide encoding 218 amino acids of the carboxy terminal noncollagenous domain of the human .alpha.3 chain of type IV collagen. Such polynucleotides are useful to express large amounts of proteins in vectors and such expressed proteins are useful to detect Goodpasture antibodies in blood and to remove Goodpasture antibodies from the bloodstream of patients suffering from Goodpasture syndrome.
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Published date: 28 December 1999
Organisations:
Medical Education
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Local EPrints ID: 399579
URI: http://eprints.soton.ac.uk/id/eprint/399579
PURE UUID: de6c1ae1-57aa-40c5-aca9-7b69c261a29d
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Date deposited: 18 Aug 2016 14:11
Last modified: 11 Dec 2021 11:30
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Contributors
Inventor:
Stephen T. Reeders
Inventor:
Karen E. Morrison
Inventor:
Billy G. Hudson
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