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Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside

Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside
Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside
Solid tumours comprise, not only malignant cells but also a variety of stromal cells and extracellular matrix proteins. These components interact via an array of signalling pathways to create an adaptable network that may act to promote or suppress cancer progression. To date, the majority of anti-tumour chemotherapeutic agents have principally sought to target the cancer cell. Consequently, resistance develops because of clonal evolution, as a result of selection pressure during tumour expansion. The concept of activating or inhibiting other cell types within the tumour microenvironment is relatively novel and has the advantage of targeting cells which are genetically stable and less likely to develop resistance. This review outlines key players in the stromal tumour microenvironment and discusses potential targeting strategies that may offer therapeutic benefit.
9-21
Bhome, Rahul
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Al Saihati, Hajir
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Goh, Rebecca
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Bullock, Marc
e060d2b2-5e6f-449b-b8ae-f411b5a396c2
Primrose, John
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Thomas, Gareth
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Sayan, Abdulkadir
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alexander
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Al Saihati, Hajir
9d4239e9-6da5-412e-8cff-7aa125c0d438
Goh, Rebecca
2dbe79e1-ec3d-4f2f-86bf-70f33269eab8
Bullock, Marc
e060d2b2-5e6f-449b-b8ae-f411b5a396c2
Primrose, John
d85f3b28-24c6-475f-955b-ec457a3f9185
Thomas, Gareth
2ff54aa9-a766-416b-91ee-cf1c5be74106
Sayan, Abdulkadir
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alexander
b3c7aee7-46a4-404c-bfe3-f72388e0bc94

Bhome, Rahul, Al Saihati, Hajir, Goh, Rebecca, Bullock, Marc, Primrose, John, Thomas, Gareth, Sayan, Abdulkadir and Mirnezami, Alexander (2016) Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside. New Horizons in Translational Medicine, 3 (1), 9-21. (doi:10.1016/j.nhtm.2016.03.001). (PMID:27275004)

Record type: Article

Abstract

Solid tumours comprise, not only malignant cells but also a variety of stromal cells and extracellular matrix proteins. These components interact via an array of signalling pathways to create an adaptable network that may act to promote or suppress cancer progression. To date, the majority of anti-tumour chemotherapeutic agents have principally sought to target the cancer cell. Consequently, resistance develops because of clonal evolution, as a result of selection pressure during tumour expansion. The concept of activating or inhibiting other cell types within the tumour microenvironment is relatively novel and has the advantage of targeting cells which are genetically stable and less likely to develop resistance. This review outlines key players in the stromal tumour microenvironment and discusses potential targeting strategies that may offer therapeutic benefit.

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Accepted/In Press date: 24 March 2016
e-pub ahead of print date: 28 March 2016
Published date: 28 March 2016
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 399581
URI: http://eprints.soton.ac.uk/id/eprint/399581
PURE UUID: 77523733-972c-48ff-893c-b9ca2b6f295c
ORCID for John Primrose: ORCID iD orcid.org/0000-0002-2069-7605

Catalogue record

Date deposited: 19 Aug 2016 13:24
Last modified: 17 Dec 2019 01:59

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Contributors

Author: Rahul Bhome
Author: Hajir Al Saihati
Author: Rebecca Goh
Author: Marc Bullock
Author: John Primrose ORCID iD
Author: Gareth Thomas

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