Recovery of sit-to-stand function in patients with intensive-care-unit-acquired muscle weakness: results from the General Weakness Syndrome Therapy cohort study

Abstract

Objectives: To describe the time course of recovery of sit-to-stand function in patients with intensive-care-unit-acquired muscle weakness and the impact of recovery.
Methods: A cohort study in post-acute intensive care unit and rehabilitation units. Patients with chronic critical illness and intensive-care-unit-acquired muscle weakness were included. Sit-to-stand function was measured daily, using a standardized chair height, defined as 120% of the individual’s knee height.
Results: A total of 150 patients were recruited according to the selection criteria.
The primary outcome of independent sit-to-stand function was achieved by a median of 56 days (interquartile range Q1–Q3=32–90 days) after rehabilitation onset and a median of 113 days (Q1–Q3=70–148 days) after onset of illness. The final multivariate model for recovery of sit-to-stand function included 3 variables: age (adjusted hazard ratio (HR)=0.96 (95% CI 0.94–0.99), duration of
ventilation (HR=0.99 (95% CI 0.98–1.00) and Functional Status Score for the Intensive Care Unit (FSS-ICU) (adjusted HR=1.12 (95% CI 1.08–1.16)).
Conclusion: Rapid recovery of sit-to-stand function for most patients with intensive-care-unit-acquired muscle weakness was seen. The variables older age and longer duration of ventilation decreased, and higher FSS-ICU increased the chance of regaining independent sit-to-stand function.

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ORCID for Jane H. Burridge: orcid.org/0000-0003-3497-6725

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