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What is the impact of n-3 PUFAs on inflammation markers in Type 2 diabetic mellitus populations?: a systematic review and meta-analysis of randomized controlled trials

What is the impact of n-3 PUFAs on inflammation markers in Type 2 diabetic mellitus populations?: a systematic review and meta-analysis of randomized controlled trials
What is the impact of n-3 PUFAs on inflammation markers in Type 2 diabetic mellitus populations?: a systematic review and meta-analysis of randomized controlled trials
Objectives

To explore the possible role of n-3 polyunsaturated fatty acids (PUFAs) in lowering inflammation markers in individuals with type 2 diabetes mellitus.

Methods

PubMed, CNKI and Cochrane databases were searched until December 30, 2015; references from papers or reviews were also retrieved and screened. Screening was performed by two independent researchers, and randomized controlled trials reporting the specific n-3 PUFA type, dose, frequency, and duration of treatment, as well as the baseline and follow-up concentrations of inflammation markers, including interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-?) and C-reactive protein (CRP), were selected for final analysis. Data analysis was performed using RevMan 5.2 software.

Results

Eight studies involving 955 participants were included; all reported CRP. Only one included study reported IL-2 or IL-6 while two studies reported TNF-?. N-3 PUFAs significantly reduced CRP concentration compared with control [SMD 95 % CI, 1.90 (0.64, 3.16), Z?=?2.96, P?=?0.003, random effect model].

Conclusions

N-3 PUFAs decrease CRP concentration in type-2 diabetes mellitus. However, larger and rigorously designed RCTs are required to confirm this finding and extend it into other inflammatory biomarkers.
N-3 PUFAs, inflammation markers, type 2 diabetes mellitus, fish oil
1-8
Lin, N.
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Shi, J.J.
9885af5c-8bf4-40c6-ab71-2a1267601de0
Li, Y.M.
b33f73d4-72dc-41f4-9b17-c4882e99af9e
Zhang, X.Y.
c045da54-1999-4f09-8a67-fa39e70d939f
Chen, Y.
aa3aa967-2aa4-499c-9265-8e6a7e7fb9e5
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Tang, L.J.
7ee5621b-b012-4d2f-a759-421dd0df5079
Lin, N.
06a21273-217d-46e2-8285-dc03eef22050
Shi, J.J.
9885af5c-8bf4-40c6-ab71-2a1267601de0
Li, Y.M.
b33f73d4-72dc-41f4-9b17-c4882e99af9e
Zhang, X.Y.
c045da54-1999-4f09-8a67-fa39e70d939f
Chen, Y.
aa3aa967-2aa4-499c-9265-8e6a7e7fb9e5
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Tang, L.J.
7ee5621b-b012-4d2f-a759-421dd0df5079

Lin, N., Shi, J.J., Li, Y.M., Zhang, X.Y., Chen, Y., Calder, P. and Tang, L.J. (2016) What is the impact of n-3 PUFAs on inflammation markers in Type 2 diabetic mellitus populations?: a systematic review and meta-analysis of randomized controlled trials. Lipids in Health and Disease, 15 (133), 1-8. (doi:10.1186/s12944-016-0303-7). (PMID:27544079)

Record type: Article

Abstract

Objectives

To explore the possible role of n-3 polyunsaturated fatty acids (PUFAs) in lowering inflammation markers in individuals with type 2 diabetes mellitus.

Methods

PubMed, CNKI and Cochrane databases were searched until December 30, 2015; references from papers or reviews were also retrieved and screened. Screening was performed by two independent researchers, and randomized controlled trials reporting the specific n-3 PUFA type, dose, frequency, and duration of treatment, as well as the baseline and follow-up concentrations of inflammation markers, including interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-?) and C-reactive protein (CRP), were selected for final analysis. Data analysis was performed using RevMan 5.2 software.

Results

Eight studies involving 955 participants were included; all reported CRP. Only one included study reported IL-2 or IL-6 while two studies reported TNF-?. N-3 PUFAs significantly reduced CRP concentration compared with control [SMD 95 % CI, 1.90 (0.64, 3.16), Z?=?2.96, P?=?0.003, random effect model].

Conclusions

N-3 PUFAs decrease CRP concentration in type-2 diabetes mellitus. However, larger and rigorously designed RCTs are required to confirm this finding and extend it into other inflammatory biomarkers.

Text
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More information

Accepted/In Press date: 9 August 2016
e-pub ahead of print date: 20 August 2016
Published date: 20 August 2016
Keywords: N-3 PUFAs, inflammation markers, type 2 diabetes mellitus, fish oil
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 400266
URI: http://eprints.soton.ac.uk/id/eprint/400266
PURE UUID: af3c45ec-cc73-49b5-8a5b-428da60eee4b
ORCID for P. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 12 Sep 2016 14:37
Last modified: 11 Mar 2021 02:35

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