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Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma: technique and results

Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma: technique and results
Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma: technique and results
BackgroundLaparoscopic left pancreatectomy has been well described for benign pancreatic lesions, but its role in pancreatic adenocarcinoma remains open to debate. We report our results adopting a laparoscopic technique that obeys established oncologic principles of open distal pancreatosplenectomy.MethodsThis is a post hoc analysis of a prospectively kept database of 135 consecutive patients undergoing laparoscopic left pancreatectomy, performed across two sites in the UK and the Netherlands (07/2007–07/2015 Southampton and 10/2013–07/2015 Amsterdam). Primary outcomes were resection margin and lymph node retrieval. Secondary endpoints were other perioperative outcomes, including post-operative pancreatic fistula. Definition of radical resection was distance tumour to resection margin >1 mm. All patients underwent ‘laparoscopic radical left pancreatosplenectomy’ (LRLP) which involves ‘hanging’ the pancreas including Gerota’s fascia, followed by clockwise dissection, including formal lymphadenectomy.ResultsLRLP for pancreatic adenocarcinoma was performed in 25 patients. Seven of the 25 patients (28 %) had extended resections, including the adrenal gland (n = 3), duodenojejunal flexure (n = 2) or transverse mesocolon (n = 3). Mean age was 68 years (54–81). Conversion rate was 0 %, mean operative time 240 min and mean blood loss 340 ml. Median intensive/high care and hospital stay were 1 and 5 days, respectively. Clavien–Dindo score 3+ complication rate was 12 % and ISGPF grade B/C pancreatic fistula rate 28 %; 90-day (or in-hospital) mortality was 0 %. The pancreatic resection margin was clear in all patients, and the posterior margin was involved (<1 mm) in 6 patients, meaning an overall R0 resection rate of 76 %. No resection margin was microscopically involved. Median nodal sample was 15 nodes (3–26). With an average follow-up of 17.2 months, 1-year survival was 88 %.ConclusionsA standardised laparoscopic approach to pancreatic adenocarcinoma in the left pancreas can be adopted safely. Our study shows that these results can be reproduced across multiple sites using the same technique.
0930-2794
3830-3838
Abu Hilal, M.
384e1c60-8519-4eed-8e92-91775aad4c47
Richardson, J.R.C.
46a21c4a-9c5a-4ebc-bd96-ff4d5cfb6989
de Rooij, T.
f2e3148e-3b0e-4573-99d0-fc4211d687a1
Dimovska, E.
ed668ba1-aea4-407c-87fe-cbf715b4ac5d
Al-Saati, H.
bba0dcae-6818-43d4-999c-d40e1d262b76
Besselink, M.G.
701b782f-4e07-4b9f-a75f-af28a6aa8cd9
Abu Hilal, M.
384e1c60-8519-4eed-8e92-91775aad4c47
Richardson, J.R.C.
46a21c4a-9c5a-4ebc-bd96-ff4d5cfb6989
de Rooij, T.
f2e3148e-3b0e-4573-99d0-fc4211d687a1
Dimovska, E.
ed668ba1-aea4-407c-87fe-cbf715b4ac5d
Al-Saati, H.
bba0dcae-6818-43d4-999c-d40e1d262b76
Besselink, M.G.
701b782f-4e07-4b9f-a75f-af28a6aa8cd9

Abu Hilal, M., Richardson, J.R.C., de Rooij, T., Dimovska, E., Al-Saati, H. and Besselink, M.G. (2016) Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma: technique and results. Surgical Endoscopy, 30 (9), 3830-3838. (doi:10.1007/s00464-015-4685-9). (PMID:26675941)

Record type: Article

Abstract

BackgroundLaparoscopic left pancreatectomy has been well described for benign pancreatic lesions, but its role in pancreatic adenocarcinoma remains open to debate. We report our results adopting a laparoscopic technique that obeys established oncologic principles of open distal pancreatosplenectomy.MethodsThis is a post hoc analysis of a prospectively kept database of 135 consecutive patients undergoing laparoscopic left pancreatectomy, performed across two sites in the UK and the Netherlands (07/2007–07/2015 Southampton and 10/2013–07/2015 Amsterdam). Primary outcomes were resection margin and lymph node retrieval. Secondary endpoints were other perioperative outcomes, including post-operative pancreatic fistula. Definition of radical resection was distance tumour to resection margin >1 mm. All patients underwent ‘laparoscopic radical left pancreatosplenectomy’ (LRLP) which involves ‘hanging’ the pancreas including Gerota’s fascia, followed by clockwise dissection, including formal lymphadenectomy.ResultsLRLP for pancreatic adenocarcinoma was performed in 25 patients. Seven of the 25 patients (28 %) had extended resections, including the adrenal gland (n = 3), duodenojejunal flexure (n = 2) or transverse mesocolon (n = 3). Mean age was 68 years (54–81). Conversion rate was 0 %, mean operative time 240 min and mean blood loss 340 ml. Median intensive/high care and hospital stay were 1 and 5 days, respectively. Clavien–Dindo score 3+ complication rate was 12 % and ISGPF grade B/C pancreatic fistula rate 28 %; 90-day (or in-hospital) mortality was 0 %. The pancreatic resection margin was clear in all patients, and the posterior margin was involved (<1 mm) in 6 patients, meaning an overall R0 resection rate of 76 %. No resection margin was microscopically involved. Median nodal sample was 15 nodes (3–26). With an average follow-up of 17.2 months, 1-year survival was 88 %.ConclusionsA standardised laparoscopic approach to pancreatic adenocarcinoma in the left pancreas can be adopted safely. Our study shows that these results can be reproduced across multiple sites using the same technique.

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Accepted/In Press date: 14 November 2015
e-pub ahead of print date: 16 December 2015
Published date: September 2016
Organisations: Cancer Sciences

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Local EPrints ID: 400308
URI: http://eprints.soton.ac.uk/id/eprint/400308
ISSN: 0930-2794
PURE UUID: b7ab93dd-73d7-4a4e-83b2-4f35281385be

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Date deposited: 14 Sep 2016 10:21
Last modified: 16 Dec 2019 19:44

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Contributors

Author: M. Abu Hilal
Author: J.R.C. Richardson
Author: T. de Rooij
Author: E. Dimovska
Author: H. Al-Saati
Author: M.G. Besselink

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