Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity
Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity
New oxathiazinane dioxides have been derived from d- and l-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC50 ≈ 10 µM.
5353-5356
Borcard, Françoise
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Baud, Matthias
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Bello, Claudia
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Dal Bello, Giovanna
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Grossi, Francesco
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Pronzato, Paolo
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Cea, Michele
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Nencioni, Alessio
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Vogel, Pierre
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1 September 2010
Borcard, Françoise
bc0c007f-cd83-4aaa-bb5d-3804c10cff5b
Baud, Matthias
8752d519-3d33-43b6-9a77-ab731d410c2e
Bello, Claudia
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Dal Bello, Giovanna
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Grossi, Francesco
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Pronzato, Paolo
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Cea, Michele
f9e3ec46-c7d1-43df-b8d1-ee2d07f9c259
Nencioni, Alessio
3d7ba8e1-fff3-4c39-94b8-510d59af44eb
Vogel, Pierre
f2987aa5-2f2d-48d7-83b8-bd1e02241909
Borcard, Françoise, Baud, Matthias, Bello, Claudia, Dal Bello, Giovanna, Grossi, Francesco, Pronzato, Paolo, Cea, Michele, Nencioni, Alessio and Vogel, Pierre
(2010)
Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity.
Bioorganic & Medicinal Chemistry Letters, 20 (17), .
(doi:10.1016/j.bmcl.2009.09.019).
Abstract
New oxathiazinane dioxides have been derived from d- and l-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC50 ≈ 10 µM.
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Accepted/In Press date: 4 September 2009
e-pub ahead of print date: 10 September 2009
Published date: 1 September 2010
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Local EPrints ID: 400518
URI: http://eprints.soton.ac.uk/id/eprint/400518
ISSN: 0960-894X
PURE UUID: 1b9127a3-e9d8-4550-b5de-1e6bea5fea77
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Date deposited: 21 Sep 2016 15:31
Last modified: 15 Mar 2024 03:54
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Author:
Françoise Borcard
Author:
Claudia Bello
Author:
Giovanna Dal Bello
Author:
Francesco Grossi
Author:
Paolo Pronzato
Author:
Michele Cea
Author:
Alessio Nencioni
Author:
Pierre Vogel
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