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Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles

Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles
Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles
The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity. Here we show for the first time a new design of nanoparticulate drug carriers that can specifically distinguish different cell types based on their mRNA signature. These nanoparticles sense and efficiently kill model tumour cells by the delivery of an anti-cancer drug but retain their payload in cells lacking the specific mRNA target.
2040-3364
16857-16861
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
El-Sagheer, Afaf H.
0bf56d90-78ee-4772-add8-453ccacc39be
Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
El-Sagheer, Afaf H.
0bf56d90-78ee-4772-add8-453ccacc39be
Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Heuer-Jungemann, Amelie, El-Sagheer, Afaf H., Lackie, Peter M., Brown, Tom and Kanaras, Antonios G. (2016) Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. Nanoscale, 8 (38), 16857-16861. (doi:10.1039/c6nr06154k).

Record type: Article

Abstract

The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity. Here we show for the first time a new design of nanoparticulate drug carriers that can specifically distinguish different cell types based on their mRNA signature. These nanoparticles sense and efficiently kill model tumour cells by the delivery of an anti-cancer drug but retain their payload in cells lacking the specific mRNA target.

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eprints_Kanaras_Revised_manuscript_Nanoscale.pdf - Accepted Manuscript
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More information

Accepted/In Press date: 8 September 2016
e-pub ahead of print date: 16 September 2016
Published date: 14 October 2016
Organisations: Quantum, Light & Matter Group

Identifiers

Local EPrints ID: 400559
URI: https://eprints.soton.ac.uk/id/eprint/400559
ISSN: 2040-3364
PURE UUID: 2cd38b4e-c5a6-4e9e-9524-55277fc2c007
ORCID for Peter M. Lackie: ORCID iD orcid.org/0000-0001-7138-3764
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 19 Sep 2016 10:57
Last modified: 06 Jun 2018 13:07

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