Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles
Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles
The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity. Here we show for the first time a new design of nanoparticulate drug carriers that can specifically distinguish different cell types based on their mRNA signature. These nanoparticles sense and efficiently kill model tumour cells by the delivery of an anti-cancer drug but retain their payload in cells lacking the specific mRNA target.
16857-16861
Heuer-Jungemann, Amelie
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El-Sagheer, Afaf H.
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Lackie, Peter M.
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Brown, Tom
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Kanaras, Antonios G.
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14 October 2016
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
El-Sagheer, Afaf H.
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Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Brown, Tom
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Kanaras, Antonios G.
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Heuer-Jungemann, Amelie, El-Sagheer, Afaf H., Lackie, Peter M., Brown, Tom and Kanaras, Antonios G.
(2016)
Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles.
Nanoscale, 8 (38), .
(doi:10.1039/c6nr06154k).
Abstract
The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity. Here we show for the first time a new design of nanoparticulate drug carriers that can specifically distinguish different cell types based on their mRNA signature. These nanoparticles sense and efficiently kill model tumour cells by the delivery of an anti-cancer drug but retain their payload in cells lacking the specific mRNA target.
Text
eprints_Kanaras_Revised_manuscript_Nanoscale.pdf
- Accepted Manuscript
More information
Accepted/In Press date: 8 September 2016
e-pub ahead of print date: 16 September 2016
Published date: 14 October 2016
Organisations:
Quantum, Light & Matter Group
Identifiers
Local EPrints ID: 400559
URI: http://eprints.soton.ac.uk/id/eprint/400559
ISSN: 2040-3364
PURE UUID: 2cd38b4e-c5a6-4e9e-9524-55277fc2c007
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Date deposited: 19 Sep 2016 10:57
Last modified: 15 Mar 2024 05:54
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Contributors
Author:
Amelie Heuer-Jungemann
Author:
Afaf H. El-Sagheer
Author:
Tom Brown
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