The University of Southampton
University of Southampton Institutional Repository

Development of a core outcome set for use in determining the overall success of gastroschisis treatment.

Development of a core outcome set for use in determining the overall success of gastroschisis treatment.
Development of a core outcome set for use in determining the overall success of gastroschisis treatment.
Background: Gastroschisis research is limited in quality by the presence of significant heterogeneity in outcome measure reporting (PloS One 10(1):e0116908, 2015). Using core outcome sets in research is one proposed method for addressing this problem (Trials 13:103, 2012; Clin Rheumatol 33(9):1313-1322, 2014; Health Serv Res Policy 17(1):1-2, 2012). Ultimately, standardising outcome measure reporting will improve research quality and translate into improvements in patient care.

Methods/design: Candidate outcome measures have been identified through systematic reviews. These outcome measures will form the starting point for an online, three-phase Delphi process that will be carried out in parallel by three panels of experts. Panel 1 is a neonatal panel, panel 2 is a non-neonatal panel and panel 3 is a lay panel.

In round 1, experts will be asked to score the previously identified outcome measures from 1–9 based on how important they think the measures are in determining the overall success of their/their child’s/their patient’s gastroschisis treatment.

In round 2, experts will be presented with the same list of outcome measures and with graphical representations of how their panel scored that outcome in round 1. They will be asked to re-score the outcome measure taking into account how important other members of their panel felt it to be. In round 3, experts will again be asked to re-score each outcome measure, but this time they will receive a graphical representation of the distribution of scores from all three panels which they should take into account when re-scoring.

Following round 3 of the Delphi process, 40 experts will be invited to attend a face-to-face consensus meeting. Participants will be invited in a purposive manner to obtain balance between the different panels. The results of the Delphi process will be discussed, and outcomes re-scored. Outcome measures where?>?70 % of the participants at the meeting scored them as 7–9 and?<?15 % scored them as 1–3 will form the core outcome set.

Discussion: Development of a core outcome set will help to reduce the heterogeneity of the outcome measure reporting in gastroschisis. This will increase the quality of research taking place and ultimately improve care provided to infants with gastroschisis.
1745-6215
1-7
Allin, Benjamin
38689f5b-299a-45b0-9c61-7619ca524602
Ross, Andrew
57aae17f-19bc-4c5f-80e7-833dec361f03
Marven, Sean
dae9c98a-68ed-4a1b-9fde-0e4d6152e0d3
Hall, Nigel J
6919e8af-3890-42c1-98a7-c110791957cf
Knight, Marian
7cfa08c5-3235-4c6c-b5f9-aa784379d4e0
Allin, Benjamin
38689f5b-299a-45b0-9c61-7619ca524602
Ross, Andrew
57aae17f-19bc-4c5f-80e7-833dec361f03
Marven, Sean
dae9c98a-68ed-4a1b-9fde-0e4d6152e0d3
Hall, Nigel J
6919e8af-3890-42c1-98a7-c110791957cf
Knight, Marian
7cfa08c5-3235-4c6c-b5f9-aa784379d4e0

Allin, Benjamin, Ross, Andrew, Marven, Sean, Hall, Nigel J and Knight, Marian (2016) Development of a core outcome set for use in determining the overall success of gastroschisis treatment. Trials, 17 (360), 1-7. (doi:10.1186/s13063-016-1453-7). (PMID:27465672)

Record type: Article

Abstract

Background: Gastroschisis research is limited in quality by the presence of significant heterogeneity in outcome measure reporting (PloS One 10(1):e0116908, 2015). Using core outcome sets in research is one proposed method for addressing this problem (Trials 13:103, 2012; Clin Rheumatol 33(9):1313-1322, 2014; Health Serv Res Policy 17(1):1-2, 2012). Ultimately, standardising outcome measure reporting will improve research quality and translate into improvements in patient care.

Methods/design: Candidate outcome measures have been identified through systematic reviews. These outcome measures will form the starting point for an online, three-phase Delphi process that will be carried out in parallel by three panels of experts. Panel 1 is a neonatal panel, panel 2 is a non-neonatal panel and panel 3 is a lay panel.

In round 1, experts will be asked to score the previously identified outcome measures from 1–9 based on how important they think the measures are in determining the overall success of their/their child’s/their patient’s gastroschisis treatment.

In round 2, experts will be presented with the same list of outcome measures and with graphical representations of how their panel scored that outcome in round 1. They will be asked to re-score the outcome measure taking into account how important other members of their panel felt it to be. In round 3, experts will again be asked to re-score each outcome measure, but this time they will receive a graphical representation of the distribution of scores from all three panels which they should take into account when re-scoring.

Following round 3 of the Delphi process, 40 experts will be invited to attend a face-to-face consensus meeting. Participants will be invited in a purposive manner to obtain balance between the different panels. The results of the Delphi process will be discussed, and outcomes re-scored. Outcome measures where?>?70 % of the participants at the meeting scored them as 7–9 and?<?15 % scored them as 1–3 will form the core outcome set.

Discussion: Development of a core outcome set will help to reduce the heterogeneity of the outcome measure reporting in gastroschisis. This will increase the quality of research taking place and ultimately improve care provided to infants with gastroschisis.

Text
Gastroschisis COS development protocol Allin Trials 2016.pdf - Version of Record
Available under License Creative Commons Attribution.
Download (451kB)

More information

Accepted/In Press date: 1 June 2016
e-pub ahead of print date: 27 July 2016
Published date: 27 July 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 400648
URI: https://eprints.soton.ac.uk/id/eprint/400648
ISSN: 1745-6215
PURE UUID: 41b866b3-abf5-4ad4-9d6e-74eabeff0eca
ORCID for Nigel J Hall: ORCID iD orcid.org/0000-0001-8570-9374

Catalogue record

Date deposited: 21 Sep 2016 08:24
Last modified: 06 Jun 2018 12:31

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×