The epigenomic interface between genome and environment in common complex diseases
The epigenomic interface between genome and environment in common complex diseases
The epigenome plays the pivotal role as interface between genome and environment. True genome-wide assessments of epigenetic marks, such as DNA methylation (methylomes) or chromatin modifications (chromatinomes), are now possible, either through high-throughput arrays or increasingly by second-generation DNA sequencing methods. The ability to collect these data at this level of resolution enables us to begin to be able to propose detailed questions, and interrogate this information, with regards to changes that occur due to development, lineage and tissue-specificity, and significantly those caused by environmental influence, such as ageing, stress, diet, hormones or toxins. Common complex traits are under variable levels of genetic influence and additionally epigenetic effect. The detection of pathological epigenetic alterations will reveal additional insights into their aetiology and how possible environmental modulation of this mechanism may occur. Due to the reversibility of these marks, the potential for sequence-specific targeted therapeutics exists. This review surveys recent epigenomic advances and their current and prospective application to the study of common diseases
477-85
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
Beck, Stephan
50f0c07a-19a8-4bca-adbc-af41a3800412
December 2010
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
Beck, Stephan
50f0c07a-19a8-4bca-adbc-af41a3800412
Bell, Christopher G. and Beck, Stephan
(2010)
The epigenomic interface between genome and environment in common complex diseases.
Briefings in Functional Genomics, 9 (5-6), .
(doi:10.1093/bfgp/elq026).
Abstract
The epigenome plays the pivotal role as interface between genome and environment. True genome-wide assessments of epigenetic marks, such as DNA methylation (methylomes) or chromatin modifications (chromatinomes), are now possible, either through high-throughput arrays or increasingly by second-generation DNA sequencing methods. The ability to collect these data at this level of resolution enables us to begin to be able to propose detailed questions, and interrogate this information, with regards to changes that occur due to development, lineage and tissue-specificity, and significantly those caused by environmental influence, such as ageing, stress, diet, hormones or toxins. Common complex traits are under variable levels of genetic influence and additionally epigenetic effect. The detection of pathological epigenetic alterations will reveal additional insights into their aetiology and how possible environmental modulation of this mechanism may occur. Due to the reversibility of these marks, the potential for sequence-specific targeted therapeutics exists. This review surveys recent epigenomic advances and their current and prospective application to the study of common diseases
Text
bell_bfg_10_epigenomic-interface.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: December 2010
Organisations:
Biomedicine, Human Development & Health, MRC Life-Course Epidemiology Unit
Identifiers
Local EPrints ID: 400988
URI: http://eprints.soton.ac.uk/id/eprint/400988
ISSN: 2041-2649
PURE UUID: 0ae41594-a7ff-467e-99bc-fa9499a7379e
Catalogue record
Date deposited: 03 Oct 2016 08:41
Last modified: 15 Mar 2024 02:35
Export record
Altmetrics
Contributors
Author:
Christopher G. Bell
Author:
Stephan Beck
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics