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The genetics of human obesity

The genetics of human obesity
The genetics of human obesity
Obesity is an important cause of morbidity and mortality in developed countries, and is also becoming increasingly prevalent in the developing world. Although environmental factors are important, there is considerable evidence that genes also have a significant role in its pathogenesis. The identification of genes that are involved in monogenic, syndromic and polygenic obesity has greatly increased our knowledge of the mechanisms that underlie this condition. In the future, dissection of the complex genetic architecture of obesity will provide new avenues for treatment and prevention, and will increase our understanding of the regulation of energy balance in humans.
1471-0056
221-234
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
Walley, Andrew J.
354e9819-2ef2-44ac-81dc-8068aa354c74
Froguel, Philippe
563ee961-98a3-4aed-98a5-d70e8350ef8c
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
Walley, Andrew J.
354e9819-2ef2-44ac-81dc-8068aa354c74
Froguel, Philippe
563ee961-98a3-4aed-98a5-d70e8350ef8c

Bell, Christopher G., Walley, Andrew J. and Froguel, Philippe (2005) The genetics of human obesity. Nature Reviews Genetics, 6 (3), 221-234. (doi:10.1038/nrg1556). (PMID:15703762)

Record type: Article

Abstract

Obesity is an important cause of morbidity and mortality in developed countries, and is also becoming increasingly prevalent in the developing world. Although environmental factors are important, there is considerable evidence that genes also have a significant role in its pathogenesis. The identification of genes that are involved in monogenic, syndromic and polygenic obesity has greatly increased our knowledge of the mechanisms that underlie this condition. In the future, dissection of the complex genetic architecture of obesity will provide new avenues for treatment and prevention, and will increase our understanding of the regulation of energy balance in humans.

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Published date: March 2005
Organisations: Human Development & Health, Centre for Biological Sciences, MRC Life-Course Epidemiology Unit

Identifiers

Local EPrints ID: 401010
URI: https://eprints.soton.ac.uk/id/eprint/401010
ISSN: 1471-0056
PURE UUID: d11ad0d3-72cc-49fc-b56a-450941450334
ORCID for Christopher G. Bell: ORCID iD orcid.org/0000-0003-4601-1242

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Date deposited: 03 Oct 2016 14:16
Last modified: 04 Aug 2018 00:30

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