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Iterative synthesis of oligo[n]rotaxanes in excellent yield

Iterative synthesis of oligo[n]rotaxanes in excellent yield
Iterative synthesis of oligo[n]rotaxanes in excellent yield
We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero-[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.
0002-7863
16329-16336
Lewis, James E.M.
42b46a03-a7ca-4d3a-96e5-a5c962fc9573
Winn, Joby
5f38d7c8-e656-4191-85c5-1323197b0bdd
Cera, Luca
71d8e90f-7651-4ccd-bc15-d87b930b3198
Goldup, Stephen M.
0a93eedd-98bb-42c1-a963-e2815665e937
Lewis, James E.M.
42b46a03-a7ca-4d3a-96e5-a5c962fc9573
Winn, Joby
5f38d7c8-e656-4191-85c5-1323197b0bdd
Cera, Luca
71d8e90f-7651-4ccd-bc15-d87b930b3198
Goldup, Stephen M.
0a93eedd-98bb-42c1-a963-e2815665e937

Lewis, James E.M., Winn, Joby, Cera, Luca and Goldup, Stephen M. (2016) Iterative synthesis of oligo[n]rotaxanes in excellent yield. Journal of the American Chemical Society, 138 (50), 16329-16336. (doi:10.1021/jacs.6b08958).

Record type: Article

Abstract

We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero-[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.

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Accepted/In Press date: 4 October 2016
e-pub ahead of print date: 18 October 2016
Published date: 21 December 2016
Organisations: Chemistry

Identifiers

Local EPrints ID: 401225
URI: http://eprints.soton.ac.uk/id/eprint/401225
ISSN: 0002-7863
PURE UUID: 2f6d91b3-44a4-4e5e-858b-52efce2ca698
ORCID for Stephen M. Goldup: ORCID iD orcid.org/0000-0003-3781-0464

Catalogue record

Date deposited: 11 Oct 2016 10:55
Last modified: 07 Oct 2020 05:28

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