Can medication effects be determined using national registry data? A cautionary reflection on risk of bias in "big data" analytics; based on Chang et al., 2016.
Can medication effects be determined using national registry data? A cautionary reflection on risk of bias in "big data" analytics; based on Chang et al., 2016.
Stimulant and non-stimulant medications are recommended as part of ADHD treatment, based on the best available evidence of their costs and benefits(1). At the same time, some important clinical questions remain to be definitively resolved. This is because of both limitations in the scope of prior trials and, in some cases, their methodological and design weaknesses. Added to this, a degree of scepticism exists, in some quarters, concerning the veracity of the ADHD medication evidence-base as a whole, because of the potentially distorting effect of pharmaceutical industry involvement in trials.
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Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Sonuga-Barke, Edmund
(2016)
Can medication effects be determined using national registry data? A cautionary reflection on risk of bias in "big data" analytics; based on Chang et al., 2016.
Biological Psychiatry, .
(doi:10.1016/j.biopsych.2016.10.002).
Abstract
Stimulant and non-stimulant medications are recommended as part of ADHD treatment, based on the best available evidence of their costs and benefits(1). At the same time, some important clinical questions remain to be definitively resolved. This is because of both limitations in the scope of prior trials and, in some cases, their methodological and design weaknesses. Added to this, a degree of scepticism exists, in some quarters, concerning the veracity of the ADHD medication evidence-base as a whole, because of the potentially distorting effect of pharmaceutical industry involvement in trials.
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- Accepted Manuscript
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Accepted/In Press date: 4 October 2016
e-pub ahead of print date: 6 October 2016
Organisations:
Clinical Neuroscience
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Local EPrints ID: 401297
URI: http://eprints.soton.ac.uk/id/eprint/401297
ISSN: 0006-3223
PURE UUID: a9bc369c-8d50-4a69-9bf7-04dc1a32a2e0
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Date deposited: 11 Oct 2016 15:31
Last modified: 15 Mar 2024 05:57
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Author:
Edmund Sonuga-Barke
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