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Combinatorial microfluidic droplet engineering for biomimetic material synthesis

Combinatorial microfluidic droplet engineering for biomimetic material synthesis
Combinatorial microfluidic droplet engineering for biomimetic material synthesis
Although droplet-based systems are used in a wide range of technologies, opportunities for systematically customizing their interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidly tailoring emulsion droplet compositions and properties. The approach uses a simple platform for screening arrays of droplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Through the application of genetic algorithms over multiple screening rounds, droplets with target properties can be rapidly generated. The potential of this method is demonstrated by creating droplets with enhanced stability, where this is achieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. The interface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible, supporting in vitro protein expression in their interiors. This general strategy will find widespread application in advancing emulsion properties for use in chemistry, biology, materials, and medicine.
2375-2548
e1600567-e1600567
Bawazer, L.A.
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McNally, C.S.
315d0c66-68c5-47f3-9faa-32a405bbcd96
Empson, C.J.
3baafd40-e5e6-46ad-a0b8-0e7bb9523e8c
Marchant, W.J.
733b756c-61a4-4af2-bb56-bbed4cf0a96a
Comyn, T.P.
d193121b-246f-41c0-82f7-6db81eed2eee
Niu, X.
f3d964fb-23b4-45db-92fe-02426e4e76fa
Cho, S.
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McPherson, M.J.
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Binks, B.P.
e031a65f-b5d4-46b8-b76e-410f244e3c2b
deMello, A.
6b370620-233f-40d8-a145-9a18d706ccba
Meldrum, F.C.
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Bawazer, L.A.
46938428-b26d-4059-827d-7e3f7a86a33f
McNally, C.S.
315d0c66-68c5-47f3-9faa-32a405bbcd96
Empson, C.J.
3baafd40-e5e6-46ad-a0b8-0e7bb9523e8c
Marchant, W.J.
733b756c-61a4-4af2-bb56-bbed4cf0a96a
Comyn, T.P.
d193121b-246f-41c0-82f7-6db81eed2eee
Niu, X.
f3d964fb-23b4-45db-92fe-02426e4e76fa
Cho, S.
cb22078b-9e28-41e1-8d59-4d04e36c505c
McPherson, M.J.
b5692963-9a52-45e4-9efb-fe9c3e3af655
Binks, B.P.
e031a65f-b5d4-46b8-b76e-410f244e3c2b
deMello, A.
6b370620-233f-40d8-a145-9a18d706ccba
Meldrum, F.C.
42c2f15d-7541-4818-919d-5f590619b1d6

Bawazer, L.A., McNally, C.S., Empson, C.J., Marchant, W.J., Comyn, T.P., Niu, X., Cho, S., McPherson, M.J., Binks, B.P., deMello, A. and Meldrum, F.C. (2016) Combinatorial microfluidic droplet engineering for biomimetic material synthesis. Science Advances, 2 (10), e1600567-e1600567. (doi:10.1126/sciadv.1600567).

Record type: Article

Abstract

Although droplet-based systems are used in a wide range of technologies, opportunities for systematically customizing their interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidly tailoring emulsion droplet compositions and properties. The approach uses a simple platform for screening arrays of droplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Through the application of genetic algorithms over multiple screening rounds, droplets with target properties can be rapidly generated. The potential of this method is demonstrated by creating droplets with enhanced stability, where this is achieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. The interface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible, supporting in vitro protein expression in their interiors. This general strategy will find widespread application in advancing emulsion properties for use in chemistry, biology, materials, and medicine.

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Accepted/In Press date: 31 August 2016
e-pub ahead of print date: 7 October 2016
Organisations: Mechatronics

Identifiers

Local EPrints ID: 401407
URI: https://eprints.soton.ac.uk/id/eprint/401407
ISSN: 2375-2548
PURE UUID: de28143e-236d-4fc9-86a4-4038949d67d7

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Date deposited: 17 Oct 2016 12:45
Last modified: 17 May 2018 16:31

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Contributors

Author: L.A. Bawazer
Author: C.S. McNally
Author: C.J. Empson
Author: W.J. Marchant
Author: T.P. Comyn
Author: X. Niu
Author: S. Cho
Author: M.J. McPherson
Author: B.P. Binks
Author: A. deMello
Author: F.C. Meldrum

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