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Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source

Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source
Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source
X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources.
1-6
Wenz, J.
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Schleede, S.
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Khrennikov, K.
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Bech, M.
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Thibault, Pierre
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Heigoldt, M.
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Pfeiffer, F.
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Karsch, S.
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Wenz, J.
15d77f93-7afe-4995-baf3-860a3da1a9f6
Schleede, S.
b105a15a-50b8-4643-8d31-dea2ac90d846
Khrennikov, K.
07d93151-3824-403e-8161-02eea4303219
Bech, M.
7e26df36-5af6-4341-9b40-6edb9b999f88
Thibault, Pierre
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Heigoldt, M.
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Pfeiffer, F.
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Karsch, S.
1214aa0f-40af-4c98-ab7b-3ee082a6de19

Wenz, J., Schleede, S., Khrennikov, K., Bech, M., Thibault, Pierre, Heigoldt, M., Pfeiffer, F. and Karsch, S. (2015) Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source. Nature Communications, 6 (7568), 1-6. (doi:10.1038/ncomms8568).

Record type: Article

Abstract

X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources.

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More information

Accepted/In Press date: 19 May 2015
Published date: 20 July 2015
Organisations: Quantum, Light & Matter Group

Identifiers

Local EPrints ID: 401537
URI: http://eprints.soton.ac.uk/id/eprint/401537
PURE UUID: 6c837677-27c1-47c7-b738-bf2604867754
ORCID for Pierre Thibault: ORCID iD orcid.org/0000-0003-1278-8846

Catalogue record

Date deposited: 13 Oct 2016 16:00
Last modified: 10 Dec 2019 01:32

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