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Sickle Cell Anemia: iron availability and nocturnal oximetry

Sickle Cell Anemia: iron availability and nocturnal oximetry
Sickle Cell Anemia: iron availability and nocturnal oximetry
Study Objective: To test the hypothesis that low iron availability, measured as transferrin saturation, is associated with low nocturnal hemoglobin oxygen saturation (SpO2) in children with homozygous sickle cell anemia (SCA; hemoglobin SS).

Methods: This was a cross-sectional study of Tanzanian children with SCA who were not receiving regular blood transfusions. Thirty-two children (16 boys) with SCA (mean age 8.0, range 3.6-15.3 years) underwent motion-resistant nocturnal oximetry (Masimo Radical) and had steady state serum transferrin saturation and hematological indices assessed.

Results: Higher transferrin saturation, adjusted for age and ?-thalassemia deletion, was associated with lower nocturnal mean SpO2 (p = 0.013, r2 = 0.41), number of SpO2 dips/h > 3% from baseline (p = 0.008, r2 = 0.19) and with min/h with SpO2 < 90% (p = 0.026 r2 = 0.16). Transferrin saturation < 16% (indicative of iron deficiency) was associated with a 2.2% higher nocturnal mean SpO2.

Conclusions: Contrary to our hypothesis, higher iron availability, assessed by transferrin saturation, is associated with nocturnal chronic and intermittent hemoglobin oxygen desaturation in SCA. Whether these associations are causal and are driven by hypoxia-inducible factor and hepcidin-mediated upregulation of demand for iron warrants further investigation.
541-545
Cox, Sharon E.
40718807-416d-47df-a663-18df62802590
L'Esperance, Veline
0d44b963-1287-432c-9913-b106064551ce
Makani, Julie
76a145a7-02fc-43ea-a1df-3a52d2004e48
Soka, Deogratius
a9467ecf-9fb7-4bd3-805d-36d1cae72f7c
Prentice, Andrew M.
6b851f61-f989-48f6-8109-9a7408254728
Hill, Catherine M.
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Kirkham, Fenella J.
7b80081e-d60f-4eb1-bfe8-cf2790e4c5bf
Cox, Sharon E.
40718807-416d-47df-a663-18df62802590
L'Esperance, Veline
0d44b963-1287-432c-9913-b106064551ce
Makani, Julie
76a145a7-02fc-43ea-a1df-3a52d2004e48
Soka, Deogratius
a9467ecf-9fb7-4bd3-805d-36d1cae72f7c
Prentice, Andrew M.
6b851f61-f989-48f6-8109-9a7408254728
Hill, Catherine M.
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Kirkham, Fenella J.
7b80081e-d60f-4eb1-bfe8-cf2790e4c5bf

Cox, Sharon E., L'Esperance, Veline, Makani, Julie, Soka, Deogratius, Prentice, Andrew M., Hill, Catherine M. and Kirkham, Fenella J. (2012) Sickle Cell Anemia: iron availability and nocturnal oximetry. Journal of Clinical Sleep Medicine, 8 (5), 541-545. (doi:10.5664/jcsm.2152).

Record type: Article

Abstract

Study Objective: To test the hypothesis that low iron availability, measured as transferrin saturation, is associated with low nocturnal hemoglobin oxygen saturation (SpO2) in children with homozygous sickle cell anemia (SCA; hemoglobin SS).

Methods: This was a cross-sectional study of Tanzanian children with SCA who were not receiving regular blood transfusions. Thirty-two children (16 boys) with SCA (mean age 8.0, range 3.6-15.3 years) underwent motion-resistant nocturnal oximetry (Masimo Radical) and had steady state serum transferrin saturation and hematological indices assessed.

Results: Higher transferrin saturation, adjusted for age and ?-thalassemia deletion, was associated with lower nocturnal mean SpO2 (p = 0.013, r2 = 0.41), number of SpO2 dips/h > 3% from baseline (p = 0.008, r2 = 0.19) and with min/h with SpO2 < 90% (p = 0.026 r2 = 0.16). Transferrin saturation < 16% (indicative of iron deficiency) was associated with a 2.2% higher nocturnal mean SpO2.

Conclusions: Contrary to our hypothesis, higher iron availability, assessed by transferrin saturation, is associated with nocturnal chronic and intermittent hemoglobin oxygen desaturation in SCA. Whether these associations are causal and are driven by hypoxia-inducible factor and hepcidin-mediated upregulation of demand for iron warrants further investigation.

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Published date: 2012
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 401656
URI: http://eprints.soton.ac.uk/id/eprint/401656
PURE UUID: e37e948a-c227-4f16-a476-23da91431400
ORCID for Catherine M. Hill: ORCID iD orcid.org/0000-0003-2372-5904

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Date deposited: 20 Oct 2016 15:59
Last modified: 15 Mar 2024 03:01

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Contributors

Author: Sharon E. Cox
Author: Veline L'Esperance
Author: Julie Makani
Author: Deogratius Soka
Author: Andrew M. Prentice
Author: Fenella J. Kirkham

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