Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia
Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia
Although visual problems are reported by patients with Alzheimer’s disease and dementia, studies into this particular aspect of neuropathology are scarce. The growing awareness of complex pathological processes in the ageing retina and brain however, enables us to consider this from a new perspective. Here we discuss the latest findings on the wide-ranging visual defects experienced by those suffering from Alzheimer’s disease and dementia. We propose that events leading to chronic degeneration of the retina and the brain in fact share many striking similarities. In particular, we discuss the role of the Alzheimer’s-related Amyloid beta (A?) group of peptides; that has been shown to accumulate in senescent retinas, correlated with increased risk of retinal degeneration. The high photo-oxidative retinal environment creates ideal conditions for A? aggregation, evidenced by high A?-loads reported in aged and donor eyes from patients with Age-related Macular degeneration. Consequently, longitudinal and non-invasive retinal assessments may provide invaluable information on incipient pathology and disease progression in the retina as well as the senescent brain. Such insights may not only lead to identifying new pathogenic mechanisms in the retina with implications for understanding Alzheimer’s disease, but reveal the underlying causes of visual abnormalities reported in patients with dementia.
85-108
Ratnayaka, J. Arjuna
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Lynn, Savannah
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Ratnayaka, J. Arjuna
002499b8-1a9f-45b6-9539-5ac145799dfd
Lynn, Savannah
de0c4ec2-8a3c-4b16-9e47-ea13abc32a3b
Ratnayaka, J. Arjuna and Lynn, Savannah
(2016)
Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia.
In,
Moretti, Davide Vito
(ed.)
Update on Dementia.
(Neuroscience)
Rijeka, HR.
Intech, .
(doi:10.5772/64790).
Record type:
Book Section
Abstract
Although visual problems are reported by patients with Alzheimer’s disease and dementia, studies into this particular aspect of neuropathology are scarce. The growing awareness of complex pathological processes in the ageing retina and brain however, enables us to consider this from a new perspective. Here we discuss the latest findings on the wide-ranging visual defects experienced by those suffering from Alzheimer’s disease and dementia. We propose that events leading to chronic degeneration of the retina and the brain in fact share many striking similarities. In particular, we discuss the role of the Alzheimer’s-related Amyloid beta (A?) group of peptides; that has been shown to accumulate in senescent retinas, correlated with increased risk of retinal degeneration. The high photo-oxidative retinal environment creates ideal conditions for A? aggregation, evidenced by high A?-loads reported in aged and donor eyes from patients with Age-related Macular degeneration. Consequently, longitudinal and non-invasive retinal assessments may provide invaluable information on incipient pathology and disease progression in the retina as well as the senescent brain. Such insights may not only lead to identifying new pathogenic mechanisms in the retina with implications for understanding Alzheimer’s disease, but reveal the underlying causes of visual abnormalities reported in patients with dementia.
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Alzheimer’s-Related Amyloid Beta Peptide Aggregates in the Ageing Retina- Implications for Sight Loss and Dementia.pdf
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e-pub ahead of print date: 28 September 2016
Organisations:
Faculty of Medicine
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Local EPrints ID: 401806
URI: http://eprints.soton.ac.uk/id/eprint/401806
PURE UUID: e52dd0fe-07f1-4d14-abe3-0a2c798153e7
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Date deposited: 19 Oct 2016 14:09
Last modified: 15 Mar 2024 04:02
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Author:
Savannah Lynn
Editor:
Davide Vito Moretti
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