The University of Southampton
University of Southampton Institutional Repository

Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia

Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia
Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia
Although visual problems are reported by patients with Alzheimer’s disease and dementia, studies into this particular aspect of neuropathology are scarce. The growing awareness of complex pathological processes in the ageing retina and brain however, enables us to consider this from a new perspective. Here we discuss the latest findings on the wide-ranging visual defects experienced by those suffering from Alzheimer’s disease and dementia. We propose that events leading to chronic degeneration of the retina and the brain in fact share many striking similarities. In particular, we discuss the role of the Alzheimer’s-related Amyloid beta (A?) group of peptides; that has been shown to accumulate in senescent retinas, correlated with increased risk of retinal degeneration. The high photo-oxidative retinal environment creates ideal conditions for A? aggregation, evidenced by high A?-loads reported in aged and donor eyes from patients with Age-related Macular degeneration. Consequently, longitudinal and non-invasive retinal assessments may provide invaluable information on incipient pathology and disease progression in the retina as well as the senescent brain. Such insights may not only lead to identifying new pathogenic mechanisms in the retina with implications for understanding Alzheimer’s disease, but reveal the underlying causes of visual abnormalities reported in patients with dementia.
85-108
INTECH
Ratnayaka, J. Arjuna
002499b8-1a9f-45b6-9539-5ac145799dfd
Lynn, Savannah
de0c4ec2-8a3c-4b16-9e47-ea13abc32a3b
Moretti, Davide Vito
Ratnayaka, J. Arjuna
002499b8-1a9f-45b6-9539-5ac145799dfd
Lynn, Savannah
de0c4ec2-8a3c-4b16-9e47-ea13abc32a3b
Moretti, Davide Vito

(2016) Alzheimer’s-related amyloid beta peptide aggregates in the ageing retina: implications for sight loss and dementia. In, Moretti, Davide Vito (ed.) Update on Dementia. (Neuroscience, , (doi:10.5772/64790)) Rijeka, HR. INTECH, pp. 85-108. (doi:10.5772/64790).

Record type: Book Section

Abstract

Although visual problems are reported by patients with Alzheimer’s disease and dementia, studies into this particular aspect of neuropathology are scarce. The growing awareness of complex pathological processes in the ageing retina and brain however, enables us to consider this from a new perspective. Here we discuss the latest findings on the wide-ranging visual defects experienced by those suffering from Alzheimer’s disease and dementia. We propose that events leading to chronic degeneration of the retina and the brain in fact share many striking similarities. In particular, we discuss the role of the Alzheimer’s-related Amyloid beta (A?) group of peptides; that has been shown to accumulate in senescent retinas, correlated with increased risk of retinal degeneration. The high photo-oxidative retinal environment creates ideal conditions for A? aggregation, evidenced by high A?-loads reported in aged and donor eyes from patients with Age-related Macular degeneration. Consequently, longitudinal and non-invasive retinal assessments may provide invaluable information on incipient pathology and disease progression in the retina as well as the senescent brain. Such insights may not only lead to identifying new pathogenic mechanisms in the retina with implications for understanding Alzheimer’s disease, but reveal the underlying causes of visual abnormalities reported in patients with dementia.

Text
Alzheimer’s-Related Amyloid Beta Peptide Aggregates in the Ageing Retina- Implications for Sight Loss and Dementia.pdf - Version of Record
Available under License Other.
Download (5MB)

More information

e-pub ahead of print date: 28 September 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 401806
URI: http://eprints.soton.ac.uk/id/eprint/401806
PURE UUID: e52dd0fe-07f1-4d14-abe3-0a2c798153e7
ORCID for J. Arjuna Ratnayaka: ORCID iD orcid.org/0000-0002-1027-6938
ORCID for Savannah Lynn: ORCID iD orcid.org/0000-0003-2513-3144

Catalogue record

Date deposited: 19 Oct 2016 14:09
Last modified: 06 Jun 2018 12:24

Export record

Altmetrics

Contributors

Author: Savannah Lynn ORCID iD
Editor: Davide Vito Moretti

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×