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European shortage of purified protein derivative and its impact on tuberculosis screening practices

European shortage of purified protein derivative and its impact on tuberculosis screening practices
European shortage of purified protein derivative and its impact on tuberculosis screening practices
Setting: in June 2014, we became aware that shortages of purified protein derivative (PPD), the test substance used for the tuberculin skin test (TST), had occurred in several European health care institutions providing care for children with tuberculosis (TB).

Objective: to establish the extent of the shortage, a survey was performed.

Design: survey conducted over a 1-month period (June–July 2014) among members of the Paediatric Tuberculosis Network European Trials Group (ptbnet).

Results: thirty-five physicians from 23 European countries contributed data. The most commonly used PPD product was RT23 (Statens Serum Institut; n = 22, 63%). Twenty-one (60%) participants reported that their institution was experiencing a PPD shortage. The majority (n = 17, 81%) of those reporting a shortage were using RT23. Thirteen (37%) participants reported changes in screening practices resulting from the shortage, including sourcing PPD from alternative manufacturers, restricting remaining supplies to patients at greatest risk or replacing TST by an interferon-gamma release assay.

Conclusions: the data show that a PPD shortage occurred in 2014, affecting multiple European countries. The shortage resulted in changes in TB screening capabilities and practices, potentially compromising both patient care as well as public health efforts. Appropriate actions to prevent future PPD shortages should be explored urgently by public health agencies and key stakeholders
1027-3719
1293-1299
Tebruegge, Marc
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Buonsenso, Danilo
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Brinkmann, Folke
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Antoni, Noguera-Julian
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Ivan, Pavić
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Adriana, Sorete Arbore
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Zuzana, Vančíková
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Svetlana, Velizarova
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Steven B, Welch
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Nicole, Ritz
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Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Buonsenso, Danilo
0cf15f9e-af83-4dfc-b50e-312bdbd0791d
Brinkmann, Folke
7a1cc254-5132-4853-8fba-c3f219f33396
Antoni, Noguera-Julian
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Ivan, Pavić
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Adriana, Sorete Arbore
e87c472d-2e48-4dd6-a9b8-44d814a74a47
Zuzana, Vančíková
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Svetlana, Velizarova
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Steven B, Welch
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Nicole, Ritz
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Tebruegge, Marc, Buonsenso, Danilo, Brinkmann, Folke, Antoni, Noguera-Julian, Ivan, Pavić, Adriana, Sorete Arbore, Zuzana, Vančíková, Svetlana, Velizarova, Steven B, Welch and Nicole, Ritz (2016) European shortage of purified protein derivative and its impact on tuberculosis screening practices. International Journal of Tuberculosis and Lung Disease, 20 (10), 1293-1299. (doi:10.5588/ijtld.15.0975). (PMID:27725037)

Record type: Article

Abstract

Setting: in June 2014, we became aware that shortages of purified protein derivative (PPD), the test substance used for the tuberculin skin test (TST), had occurred in several European health care institutions providing care for children with tuberculosis (TB).

Objective: to establish the extent of the shortage, a survey was performed.

Design: survey conducted over a 1-month period (June–July 2014) among members of the Paediatric Tuberculosis Network European Trials Group (ptbnet).

Results: thirty-five physicians from 23 European countries contributed data. The most commonly used PPD product was RT23 (Statens Serum Institut; n = 22, 63%). Twenty-one (60%) participants reported that their institution was experiencing a PPD shortage. The majority (n = 17, 81%) of those reporting a shortage were using RT23. Thirteen (37%) participants reported changes in screening practices resulting from the shortage, including sourcing PPD from alternative manufacturers, restricting remaining supplies to patients at greatest risk or replacing TST by an interferon-gamma release assay.

Conclusions: the data show that a PPD shortage occurred in 2014, affecting multiple European countries. The shortage resulted in changes in TB screening capabilities and practices, potentially compromising both patient care as well as public health efforts. Appropriate actions to prevent future PPD shortages should be explored urgently by public health agencies and key stakeholders

Text
Tebruegge et al - European PPD shortage - manuscript - accepted version for ePrints (combined).pdf - Accepted Manuscript
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Accepted/In Press date: 9 May 2016
e-pub ahead of print date: 1 October 2016
Published date: 1 October 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 402106
URI: https://eprints.soton.ac.uk/id/eprint/402106
ISSN: 1027-3719
PURE UUID: 051d6f2c-3e63-497f-959a-2193c91d9bb9

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Date deposited: 31 Oct 2016 11:33
Last modified: 03 Dec 2019 06:29

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Contributors

Author: Marc Tebruegge
Author: Danilo Buonsenso
Author: Folke Brinkmann
Author: Noguera-Julian Antoni
Author: Pavić Ivan
Author: Sorete Arbore Adriana
Author: Vančíková Zuzana
Author: Velizarova Svetlana
Author: Welch Steven B
Author: Ritz Nicole

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