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Greater variation in affect is associated with lower fasting plasma glucose

Greater variation in affect is associated with lower fasting plasma glucose
Greater variation in affect is associated with lower fasting plasma glucose
Background

Depression and bipolar illness are associated with a 2–3 fold increase in the prevalence of diabetes. However, it is unknown whether variation in mood affects glucose metabolism. The aim of this study was to assess whether changes in affect were related to fasting plasma glucose and glycated haemoglobin.

Methods

379 men and 441 women who took part in the 2003 Health Survey for England and had valid data for GHQ12 and fasting blood glucose were included. Mood variability was assessed by the General Health Questionnaire 12 (GHQ12). Fasting plasma glucose and glycated haemoglobin (HbA1c) were measured by standard laboratory methodology and their relationship to variability assessed using linear regression.

Results

There was a significant inverse relationship between fasting blood glucose, but not HbA1c, and variability score (R2 = 0.327, p = 0.02) after adjusting for sociodemographic factors, anthropometric measurements, lifestyle, and use of medication.

Conclusion

This study has shown an inverse association between changes in affect and fasting plasma glucose. This unexpected finding suggests that the association between affect and glucose is more complex than previously thought. Fasting blood glucose may reflect the operation of homeostatic mechanisms that are disturbed in certain mental states and are associated, therefore, with altered risk of diabetes and related metabolic conditions. This may have implications for the management of those with such conditions and with mental disorders.
1-13
Gupta, S.
32658b41-cb78-4f2d-8848-f4b2e92e4fc5
Anderson, R.
394fb68e-1194-4609-80aa-f6141ced089a
Holt, R.
d54202e1-fcf6-4a17-a320-9f32d7024393
Gupta, S.
32658b41-cb78-4f2d-8848-f4b2e92e4fc5
Anderson, R.
394fb68e-1194-4609-80aa-f6141ced089a
Holt, R.
d54202e1-fcf6-4a17-a320-9f32d7024393

Gupta, S., Anderson, R. and Holt, R. (2016) Greater variation in affect is associated with lower fasting plasma glucose. Heliyon, 2 (9), 1-13. (doi:10.1016/j.heliyon.2016.e00160). (PMID:27699281)

Record type: Article

Abstract

Background

Depression and bipolar illness are associated with a 2–3 fold increase in the prevalence of diabetes. However, it is unknown whether variation in mood affects glucose metabolism. The aim of this study was to assess whether changes in affect were related to fasting plasma glucose and glycated haemoglobin.

Methods

379 men and 441 women who took part in the 2003 Health Survey for England and had valid data for GHQ12 and fasting blood glucose were included. Mood variability was assessed by the General Health Questionnaire 12 (GHQ12). Fasting plasma glucose and glycated haemoglobin (HbA1c) were measured by standard laboratory methodology and their relationship to variability assessed using linear regression.

Results

There was a significant inverse relationship between fasting blood glucose, but not HbA1c, and variability score (R2 = 0.327, p = 0.02) after adjusting for sociodemographic factors, anthropometric measurements, lifestyle, and use of medication.

Conclusion

This study has shown an inverse association between changes in affect and fasting plasma glucose. This unexpected finding suggests that the association between affect and glucose is more complex than previously thought. Fasting blood glucose may reflect the operation of homeostatic mechanisms that are disturbed in certain mental states and are associated, therefore, with altered risk of diabetes and related metabolic conditions. This may have implications for the management of those with such conditions and with mental disorders.

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More information

Accepted/In Press date: 9 September 2016
e-pub ahead of print date: 22 September 2016
Published date: September 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 402134
URI: http://eprints.soton.ac.uk/id/eprint/402134
PURE UUID: 61a081df-3d84-4cfb-a26d-cc558e3a4234
ORCID for R. Holt: ORCID iD orcid.org/0000-0001-8911-6744

Catalogue record

Date deposited: 01 Nov 2016 11:16
Last modified: 18 Feb 2021 16:56

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Contributors

Author: S. Gupta
Author: R. Anderson
Author: R. Holt ORCID iD

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