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Bone turnover predicts change in volumetric bone density and bone geometry at the radius in men

Bone turnover predicts change in volumetric bone density and bone geometry at the radius in men
Bone turnover predicts change in volumetric bone density and bone geometry at the radius in men
Purpose  To determine prospective change in bone density and geometry at the radius in men, and examine the influence of bone turnover markers and sex hormones on that change.
Methods  Men aged 40-79 years were recruited from population registers in Manchester (UK) and Leuven (Belgium). At baseline, markers of bone formation (P1NP and Osteocalcin) and resorption (β-cTX and ICTP ) were assessed. Total and bioavailable testosterone, and oestradiol were also measured. Peripheral quantitative computed tomography (pQCT) was used to scan the radius at distal and midshaft sites at baseline and a median of 4.3 years later.
Results  514 men, mean (SD) age 59.6 (10.5) years, contributed data. At the midshaft site there was a significant decrease in mean cortical volumetric BMD (vBMD) (-0.04%/year), bone mineral content (BMC) (-0.1%/year) and cortical thickness (-0.4%/year), whilst total and medullary area increased (+0.5%/year, +2.4%/year, respectively). At the distal radius, total vBMD declined (-0.5%/year) and radial area increased (+0.6%/year). Greater plasma concentrations of bone resorption and formation markers were associated with greater decline in BMC and cortical area at the midshaft and total vBMD at the distal site. Increased bone resorption was linked with an increase in total and medullary area and decrease in cortical thickness at the midshaft. Sex hormone levels were unrelated to change in pQCT parameters.
Conclusions  Age-related changes in vBMD and bone geometry are greater in men with higher biochemical markers of bone turnover at baseline. Sex hormones have little influence on change in pQCT parameters.
Mini abstract  Peripheral quantitative computed tomography scans of the distal and mid-shaft radius were performed in 514 European men aged 40-79 years at baseline and a median of 4.3 years later. Age-related changes in vBMD and bone geometry were greater in men with higher biochemical markers of bone turnover at baseline.
0937-941X
1-23
Pye, S.R.
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Ward, K.
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Cook, M.J.
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Laurent, M.R.
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Gielen, E.
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Borghs, H.
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Adams, J.E.
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Boonen, S.
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Vanderschueren, D.
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Wu, F.C.
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O'Neill, T.W.
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Pye, S.R.
b013dbd8-7479-44b1-9b46-bca03c2deb11
Ward, K.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Cook, M.J.
6961bf6c-82c6-4cfb-96c4-00daab36a988
Laurent, M.R.
ce3c6632-2909-48d9-b6d6-a8ba2b565da5
Gielen, E.
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Borghs, H.
51712192-32cb-4435-9e45-8d7d76458c5f
Adams, J.E.
a33a47cb-53dd-4f17-aebd-9dfff2485f97
Boonen, S.
19c70ece-493f-4b7c-9bf9-5e4a4a887ba4
Vanderschueren, D.
de49cace-a8d0-4ca0-bc39-274b55506a68
Wu, F.C.
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O'Neill, T.W.
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Pye, S.R., Ward, K., Cook, M.J., Laurent, M.R., Gielen, E., Borghs, H., Adams, J.E., Boonen, S., Vanderschueren, D., Wu, F.C. and O'Neill, T.W. (2016) Bone turnover predicts change in volumetric bone density and bone geometry at the radius in men. Osteoporosis International, 1-23. (In Press)

Record type: Article

Abstract

Purpose  To determine prospective change in bone density and geometry at the radius in men, and examine the influence of bone turnover markers and sex hormones on that change.
Methods  Men aged 40-79 years were recruited from population registers in Manchester (UK) and Leuven (Belgium). At baseline, markers of bone formation (P1NP and Osteocalcin) and resorption (β-cTX and ICTP ) were assessed. Total and bioavailable testosterone, and oestradiol were also measured. Peripheral quantitative computed tomography (pQCT) was used to scan the radius at distal and midshaft sites at baseline and a median of 4.3 years later.
Results  514 men, mean (SD) age 59.6 (10.5) years, contributed data. At the midshaft site there was a significant decrease in mean cortical volumetric BMD (vBMD) (-0.04%/year), bone mineral content (BMC) (-0.1%/year) and cortical thickness (-0.4%/year), whilst total and medullary area increased (+0.5%/year, +2.4%/year, respectively). At the distal radius, total vBMD declined (-0.5%/year) and radial area increased (+0.6%/year). Greater plasma concentrations of bone resorption and formation markers were associated with greater decline in BMC and cortical area at the midshaft and total vBMD at the distal site. Increased bone resorption was linked with an increase in total and medullary area and decrease in cortical thickness at the midshaft. Sex hormone levels were unrelated to change in pQCT parameters.
Conclusions  Age-related changes in vBMD and bone geometry are greater in men with higher biochemical markers of bone turnover at baseline. Sex hormones have little influence on change in pQCT parameters.
Mini abstract  Peripheral quantitative computed tomography scans of the distal and mid-shaft radius were performed in 514 European men aged 40-79 years at baseline and a median of 4.3 years later. Age-related changes in vBMD and bone geometry were greater in men with higher biochemical markers of bone turnover at baseline.

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Accepted/In Press date: 18 October 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 402191
URI: http://eprints.soton.ac.uk/id/eprint/402191
ISSN: 0937-941X
PURE UUID: 1cf1f157-28b6-4ebe-941a-c4f35ad8b9ed
ORCID for K. Ward: ORCID iD orcid.org/0000-0001-7034-6750

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Date deposited: 02 Nov 2016 16:54
Last modified: 07 Oct 2020 05:11

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Contributors

Author: S.R. Pye
Author: K. Ward ORCID iD
Author: M.J. Cook
Author: M.R. Laurent
Author: E. Gielen
Author: H. Borghs
Author: J.E. Adams
Author: S. Boonen
Author: D. Vanderschueren
Author: F.C. Wu
Author: T.W. O'Neill

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