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Tuberculosis: an infection-initiated autoimmune disease?

Tuberculosis: an infection-initiated autoimmune disease?
Tuberculosis: an infection-initiated autoimmune disease?
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and provided original proof that an infectious agent can cause human disease. However, key steps in TB pathogenesis remain poorly understood. We propose that autoimmunity is a critical and overlooked process driving pathology in TB, and present clinical and experimental observations supporting this hypothesis.
1471-4906
815-818
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Mansour, Salah
4aecba5a-8387-4f7b-b766-0a9c309ccb8b
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Mansour, Salah
4aecba5a-8387-4f7b-b766-0a9c309ccb8b

Elkington, Paul, Tebruegge, Marc and Mansour, Salah (2016) Tuberculosis: an infection-initiated autoimmune disease? Trends in Immunology, 37 (12), 815-818. (doi:10.1016/j.it.2016.09.007). (PMID:27773684)

Record type: Article

Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and provided original proof that an infectious agent can cause human disease. However, key steps in TB pathogenesis remain poorly understood. We propose that autoimmunity is a critical and overlooked process driving pathology in TB, and present clinical and experimental observations supporting this hypothesis.

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Accepted/In Press date: 28 September 2016
e-pub ahead of print date: 21 October 2016
Published date: December 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 402197
URI: https://eprints.soton.ac.uk/id/eprint/402197
ISSN: 1471-4906
PURE UUID: d78ee44b-d594-4f77-b9b7-c1bdcb5e4e1e
ORCID for Paul Elkington: ORCID iD orcid.org/0000-0003-0390-0613
ORCID for Salah Mansour: ORCID iD orcid.org/0000-0002-5982-734X

Catalogue record

Date deposited: 03 Nov 2016 14:31
Last modified: 10 Dec 2019 06:21

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