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Flow motion dynamics of microvascular blood flow and oxygenation - evidence of adaptive changes in obesity and type 2 diabetes mellitus/insulin resistance

Flow motion dynamics of microvascular blood flow and oxygenation - evidence of adaptive changes in obesity and type 2 diabetes mellitus/insulin resistance
Flow motion dynamics of microvascular blood flow and oxygenation - evidence of adaptive changes in obesity and type 2 diabetes mellitus/insulin resistance
An altered spatial heterogeneity and temporal stability of network perfusion can give rise to a limited adaptive ability to meet metabolic demands. Derangement of local flow motion activity is associated with reduced microvascular blood flow and tissue oxygenation and it has been suggested that changes in flow motion activity may provide an early indicator of declining, endothelial, neurogenic and myogenic regulatory mechanisms and signal the onset and progression of microvascular pathophysiology. This short conference review article explores some of the evidence for altered flow motion dynamics of blood flux signals acquired using laser Doppler fluximetry in the skin in individuals at risk of developing or with cardio-metabolic disease.
1073-9688
1-30
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
Kuliga, Kasia
6679d3c0-c1da-46c4-aae2-cfaf0a417350
Chipperfield, Andrew
524269cd-5f30-4356-92d4-891c14c09340
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
Kuliga, Kasia
6679d3c0-c1da-46c4-aae2-cfaf0a417350
Chipperfield, Andrew
524269cd-5f30-4356-92d4-891c14c09340

Clough, Geraldine, Kuliga, Kasia and Chipperfield, Andrew (2016) Flow motion dynamics of microvascular blood flow and oxygenation - evidence of adaptive changes in obesity and type 2 diabetes mellitus/insulin resistance. Microcirculation, 1-30. (doi:10.1111/micc.12331).

Record type: Article

Abstract

An altered spatial heterogeneity and temporal stability of network perfusion can give rise to a limited adaptive ability to meet metabolic demands. Derangement of local flow motion activity is associated with reduced microvascular blood flow and tissue oxygenation and it has been suggested that changes in flow motion activity may provide an early indicator of declining, endothelial, neurogenic and myogenic regulatory mechanisms and signal the onset and progression of microvascular pathophysiology. This short conference review article explores some of the evidence for altered flow motion dynamics of blood flux signals acquired using laser Doppler fluximetry in the skin in individuals at risk of developing or with cardio-metabolic disease.

Text
Clough et al Microcirculation 2016 R1 accepted unmarked with figures and tables 181016.docx - Accepted Manuscript
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More information

Accepted/In Press date: 31 October 2016
e-pub ahead of print date: 3 November 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 402426
URI: http://eprints.soton.ac.uk/id/eprint/402426
ISSN: 1073-9688
PURE UUID: 703f9b12-024a-4dd5-a0ff-330d49ef9403
ORCID for Geraldine Clough: ORCID iD orcid.org/0000-0002-6226-8964
ORCID for Andrew Chipperfield: ORCID iD orcid.org/0000-0002-3026-9890

Catalogue record

Date deposited: 07 Nov 2016 14:06
Last modified: 07 Oct 2020 05:28

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Contributors

Author: Kasia Kuliga

University divisions

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