Mortality in the Hertfordshire Ageing Study: association with level and loss of hand grip strength in later life
Mortality in the Hertfordshire Ageing Study: association with level and loss of hand grip strength in later life
Background
Weak hand grip strength in later life is a risk factor for disability, morbidity and mortality and is central to definitions of sarcopenia and frailty. It is unclear whether rate of change in grip strength adds to level of grip strength as a risk factor for poor ageing outcomes.
Methods
Study participants were 292 community-dwelling men and women whose grip strength was measured during the 1994/5 (average age 67) and 2003/5 (average age 76) phases of the Hertfordshire Ageing Study, UK. Individual rate of change in grip strength was estimated using a residual change method. Mortality was followed-up to 2011 (42 men and 21 women died).
Results
Average grip strengths in 2003/5 were 38.4kg (standard deviation [SD] 8.1) and 23.7kg (SD 6.6) for men and women respectively. Average annualised rates of change in grip strength (2003/5 minus 1994/5) were modest owing to a healthy-participant effect (men: -0.12kg/year SD 0.71; women: 0.08kg/year SD 0.54) but varied widely. Mortality risk varied according to level and rate of change in grip strength (p=0.03); death rates per 100 person years of follow-up were 6.7 (95%CI 4.6,9.6) among participants who lost grip over time and had low grip in 2003/5, in contrast with 0.8 (95%CI 0.1,5.8) among participants whose grip changed little over time and remained high in 2003/5.
Conclusions
Levels of grip strength in later life should be considered in conjunction with estimates of change in grip strength identified by repeat measurement over time. Normative data for longitudinal change in grip strength are required.
407-412
Syddall, Holly
a0181a93-8fc3-4998-a996-7963f0128328
Westbury, Leo
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Dodds, Richard
2f7c0dea-4cd7-4f91-9fd2-a5ff20706870
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
f4c60d4a-ae9c-4633-890f-598a717a61d4
May 2017
Syddall, Holly
a0181a93-8fc3-4998-a996-7963f0128328
Westbury, Leo
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Dodds, Richard
2f7c0dea-4cd7-4f91-9fd2-a5ff20706870
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
f4c60d4a-ae9c-4633-890f-598a717a61d4
Syddall, Holly, Westbury, Leo, Dodds, Richard, Dennison, Elaine, Cooper, Cyrus and Sayer, A.A.
(2017)
Mortality in the Hertfordshire Ageing Study: association with level and loss of hand grip strength in later life.
Age and Ageing, 46 (3), .
(doi:10.1093/ageing/afw222).
Abstract
Background
Weak hand grip strength in later life is a risk factor for disability, morbidity and mortality and is central to definitions of sarcopenia and frailty. It is unclear whether rate of change in grip strength adds to level of grip strength as a risk factor for poor ageing outcomes.
Methods
Study participants were 292 community-dwelling men and women whose grip strength was measured during the 1994/5 (average age 67) and 2003/5 (average age 76) phases of the Hertfordshire Ageing Study, UK. Individual rate of change in grip strength was estimated using a residual change method. Mortality was followed-up to 2011 (42 men and 21 women died).
Results
Average grip strengths in 2003/5 were 38.4kg (standard deviation [SD] 8.1) and 23.7kg (SD 6.6) for men and women respectively. Average annualised rates of change in grip strength (2003/5 minus 1994/5) were modest owing to a healthy-participant effect (men: -0.12kg/year SD 0.71; women: 0.08kg/year SD 0.54) but varied widely. Mortality risk varied according to level and rate of change in grip strength (p=0.03); death rates per 100 person years of follow-up were 6.7 (95%CI 4.6,9.6) among participants who lost grip over time and had low grip in 2003/5, in contrast with 0.8 (95%CI 0.1,5.8) among participants whose grip changed little over time and remained high in 2003/5.
Conclusions
Levels of grip strength in later life should be considered in conjunction with estimates of change in grip strength identified by repeat measurement over time. Normative data for longitudinal change in grip strength are required.
Text
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More information
Accepted/In Press date: 1 November 2016
e-pub ahead of print date: 8 December 2016
Published date: May 2017
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 402454
URI: http://eprints.soton.ac.uk/id/eprint/402454
ISSN: 0002-0729
PURE UUID: 8f6ed235-39b9-4d77-ae17-25d50f5cc925
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Date deposited: 08 Nov 2016 16:23
Last modified: 18 Mar 2024 05:10
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Contributors
Author:
Richard Dodds
Author:
A.A. Sayer
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