The University of Southampton
University of Southampton Institutional Repository

The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey

The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey
The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey
Background: Recent reports indicate an ongoing BCG shortage that may influence immunisation practice. This study aimed to determine current availability of BCG vaccine across Europe, and implications on immunisation practices and policies in Europe.

Methods: web-based survey among Paediatric Tuberculosis Network European Trials Group (ptbnet) members, between May and October 2015.

Results: twenty individuals from 13 European countries participated. Ongoing shortages were reported in eight countries routinely using BCG (8/11, 73%). As a consequence of the shortage, BCG was not given as completely unavailable in some countries (2/8, 25%), was given only whenever available (1/8, 13%), or only in certain regions of the country (1/8, 13%). Strategies reported to reduce loss of immunisation were administration to selected high-risk individuals (2/8, 25%), or cohorting vaccinees on specific days to maximise the use of multi-dose vials (3/8, 38%). Authorities in two countries each were considering a change of manufacturer/supplier (2/8, 25%).

Conclusions: the BCG shortage in Europe leads to significant changes in immunisation policies including changes of BCG vaccine strain and manufacturer. In addition, infants and children eligible for immunisation are at risk of not receiving BCG. To ensure necessary BCG immunisations, collaboration between national health agencies and vaccine manufacturers is crucial.
1472-9792
125-129
Kontturi, Antti
2deeb7b3-78f9-432d-a6a2-d2c803d9f620
Santiago, Begoña
ba1c2da1-fedc-433a-ab4c-26c51a121e4d
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
von Both, Ulrich
fe20215e-06d4-4551-9263-662c26448bb4
Salo, Eeva
0e6cd4b9-fa1b-4317-836f-0362a1cae3f0
Ritz, Nicole
ce6604a1-f373-4d76-838a-1ae75f35b20b
Ptbnet BCG shortage project collaborators, Ptbnet
55a5f463-7b42-4997-90bf-ddac3e720106
Kontturi, Antti
2deeb7b3-78f9-432d-a6a2-d2c803d9f620
Santiago, Begoña
ba1c2da1-fedc-433a-ab4c-26c51a121e4d
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
von Both, Ulrich
fe20215e-06d4-4551-9263-662c26448bb4
Salo, Eeva
0e6cd4b9-fa1b-4317-836f-0362a1cae3f0
Ritz, Nicole
ce6604a1-f373-4d76-838a-1ae75f35b20b
Ptbnet BCG shortage project collaborators, Ptbnet
55a5f463-7b42-4997-90bf-ddac3e720106

Kontturi, Antti, Santiago, Begoña, Tebruegge, Marc, von Both, Ulrich, Salo, Eeva, Ritz, Nicole and Ptbnet BCG shortage project collaborators, Ptbnet (2016) The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey. Tuberculosis, 101, 125-129. (doi:10.1016/j.tube.2016.08.005).

Record type: Article

Abstract

Background: Recent reports indicate an ongoing BCG shortage that may influence immunisation practice. This study aimed to determine current availability of BCG vaccine across Europe, and implications on immunisation practices and policies in Europe.

Methods: web-based survey among Paediatric Tuberculosis Network European Trials Group (ptbnet) members, between May and October 2015.

Results: twenty individuals from 13 European countries participated. Ongoing shortages were reported in eight countries routinely using BCG (8/11, 73%). As a consequence of the shortage, BCG was not given as completely unavailable in some countries (2/8, 25%), was given only whenever available (1/8, 13%), or only in certain regions of the country (1/8, 13%). Strategies reported to reduce loss of immunisation were administration to selected high-risk individuals (2/8, 25%), or cohorting vaccinees on specific days to maximise the use of multi-dose vials (3/8, 38%). Authorities in two countries each were considering a change of manufacturer/supplier (2/8, 25%).

Conclusions: the BCG shortage in Europe leads to significant changes in immunisation policies including changes of BCG vaccine strain and manufacturer. In addition, infants and children eligible for immunisation are at risk of not receiving BCG. To ensure necessary BCG immunisations, collaboration between national health agencies and vaccine manufacturers is crucial.

Text
Impact of BCG shortage - accepted manuscript - combined.pdf - Accepted Manuscript
Download (247kB)

More information

Accepted/In Press date: 25 August 2016
Published date: 31 August 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 402537
URI: https://eprints.soton.ac.uk/id/eprint/402537
ISSN: 1472-9792
PURE UUID: c5300571-73e7-4c2f-8df8-9dc4dfcd2c3f

Catalogue record

Date deposited: 10 Nov 2016 14:21
Last modified: 19 Nov 2019 06:31

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×