Fibroblast activation and senescence in oral cancer
Fibroblast activation and senescence in oral cancer
There is now compelling evidence that the tumour stroma plays an important role in the pathogenesis of cancers of epithelial origin. The pre-eminent cell type of the stroma is carcinoma-associated fibroblasts. These cells demonstrate remarkable heterogeneity with activation and senescence being common stress responses. In this review, we summarise the part that these cells play in cancer, particularly oral cancer, and present evidence to show that activation and senescence reflect a unified programme of fibroblast differentiation. We report advances concerning the senescent fibroblast metabolome, mechanisms of gene regulation in these cells and ways in which epithelial cell adhesion is dysregulated by the fibroblast secretome. We suggest that the identification of fibroblast stress responses may be a valuable diagnostic tool in the determination of tumour behaviour and patient outcome. Further, the fact that stromal fibroblasts are a genetically stable diploid cell population suggests that they may be ideal therapeutic targets and early work in this context is encouraging.
1-7
Prime, S.S.
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Cirillo, N.
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Hassona, Y.
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Lambert, D.W.
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Paterson, I.C.
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Mellone, M.
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Prime, S.S.
48f6c5dd-5160-4440-bfe9-a32258f93cdb
Cirillo, N.
aee162ed-ce3d-419c-a6b5-08d3e62424ec
Hassona, Y.
88050543-9c17-400a-a722-a90c8e02aa46
Lambert, D.W.
50f238f8-53f6-41d3-b59e-4928cad5e0aa
Paterson, I.C.
5cd713ca-f24b-4cb4-bb79-e66a8809bc3d
Mellone, M.
b0301b32-14f8-4203-9026-b7f90885cab9
Prime, S.S., Cirillo, N., Hassona, Y., Lambert, D.W., Paterson, I.C. and Mellone, M.
(2016)
Fibroblast activation and senescence in oral cancer.
Journal of Oral Pathology and Medicine, .
(doi:10.1111/jop.12456).
(PMID:27237745)
Abstract
There is now compelling evidence that the tumour stroma plays an important role in the pathogenesis of cancers of epithelial origin. The pre-eminent cell type of the stroma is carcinoma-associated fibroblasts. These cells demonstrate remarkable heterogeneity with activation and senescence being common stress responses. In this review, we summarise the part that these cells play in cancer, particularly oral cancer, and present evidence to show that activation and senescence reflect a unified programme of fibroblast differentiation. We report advances concerning the senescent fibroblast metabolome, mechanisms of gene regulation in these cells and ways in which epithelial cell adhesion is dysregulated by the fibroblast secretome. We suggest that the identification of fibroblast stress responses may be a valuable diagnostic tool in the determination of tumour behaviour and patient outcome. Further, the fact that stromal fibroblasts are a genetically stable diploid cell population suggests that they may be ideal therapeutic targets and early work in this context is encouraging.
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Accepted/In Press date: 28 April 2016
e-pub ahead of print date: 30 May 2016
Organisations:
Cancer Sciences
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Local EPrints ID: 402856
URI: http://eprints.soton.ac.uk/id/eprint/402856
ISSN: 0904-2512
PURE UUID: 4a48fd63-34eb-4549-9123-71aeed96181a
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Date deposited: 16 Nov 2016 14:44
Last modified: 15 Mar 2024 03:27
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Contributors
Author:
S.S. Prime
Author:
N. Cirillo
Author:
Y. Hassona
Author:
D.W. Lambert
Author:
I.C. Paterson
Author:
M. Mellone
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