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Parental nutrition and developmental origins of health and disease

Parental nutrition and developmental origins of health and disease
Parental nutrition and developmental origins of health and disease
Human studies and animal experiments have shown that overnutrition and undernutrition during the prenatal period can induce the development of noncommunicable diseases during postnatal life. This unfavorable programming is the basis for the “developmental origins of health and disease” (DOHaD) hypothesis. This adverse developmental programming can affect offspring beyond the F1 generation and can be induced by paternal and maternal lineages. Several studies have demonstrated that altered phenotypes induced by prenatal nutrition are associated with epigenetic modifications. Nevertheless, clear cause–effect relationships between disease occurrence and epigenetic changes are not available. Research is needed to identify epigenetic marks that will assist in the development of preventive and interventional strategies against adverse developmental programming induced by nutrition during the prenatal period.
89-102
Academic Press
Velazquez, Miguel A.
0cb33ae4-eff7-445a-97a5-62a6daf71154
Sun, Congshan
adfdc328-7714-4a0c-ac23-0aede71cf3ea
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Velazquez, Miguel A.
0cb33ae4-eff7-445a-97a5-62a6daf71154
Sun, Congshan
adfdc328-7714-4a0c-ac23-0aede71cf3ea
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03

Velazquez, Miguel A., Sun, Congshan and Fleming, Tom P. (2016) Parental nutrition and developmental origins of health and disease. In, The Epigenome and Developmental Origins of Health and Disease. London, GB. Academic Press, pp. 89-102. (doi:10.1016/B978-0-12-801383-0.00006-2).

Record type: Book Section

Abstract

Human studies and animal experiments have shown that overnutrition and undernutrition during the prenatal period can induce the development of noncommunicable diseases during postnatal life. This unfavorable programming is the basis for the “developmental origins of health and disease” (DOHaD) hypothesis. This adverse developmental programming can affect offspring beyond the F1 generation and can be induced by paternal and maternal lineages. Several studies have demonstrated that altered phenotypes induced by prenatal nutrition are associated with epigenetic modifications. Nevertheless, clear cause–effect relationships between disease occurrence and epigenetic changes are not available. Research is needed to identify epigenetic marks that will assist in the development of preventive and interventional strategies against adverse developmental programming induced by nutrition during the prenatal period.

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Published date: 2016
Organisations: Centre for Biological Sciences

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Local EPrints ID: 402975
URI: http://eprints.soton.ac.uk/id/eprint/402975
PURE UUID: cd9024ac-8391-4fa6-bea0-0de04803b408

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Date deposited: 21 Nov 2016 13:27
Last modified: 15 Jul 2019 19:53

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Contributors

Author: Miguel A. Velazquez
Author: Congshan Sun
Author: Tom P. Fleming

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