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DOHaD and the periconceptional period, a critical window in time

DOHaD and the periconceptional period, a critical window in time
DOHaD and the periconceptional period, a critical window in time
Environmental conditions can modulate the developmental program and have enduring consequences on the life cycle, affecting long-term health and disease risk through to adulthood. These effects can occur through different mechanisms and at different stages of development. This chapter considers environmental factors that may occur during the periconceptional period, around the time of conception and during early embryo development, and have lasting effects on phenotype and lifetime health. We review in particular in vivo conditions of maternal dietary nutrition during periconceptional development, both poor and over-rich nutrition, and how such conditions may affect the early embryo, altering subsequent development and postnatal health. In addition, in vitro conditions that embryos may experience, in particular associated with assisted conception technologies, are reviewed. We also evaluate the importance of paternal as well as maternal environment during periconceptional induction of developmental programming. We conclude that the periconceptional environment is one of critical sensitivity for lifetime health and there is a need for continued research within this field to identify mechanisms and devise protective strategies.
33-47
Academic Press
Sun, Congshan
adfdc328-7714-4a0c-ac23-0aede71cf3ea
Velazquez, Miguel A.
0cb33ae4-eff7-445a-97a5-62a6daf71154
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Sun, Congshan
adfdc328-7714-4a0c-ac23-0aede71cf3ea
Velazquez, Miguel A.
0cb33ae4-eff7-445a-97a5-62a6daf71154
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03

Sun, Congshan, Velazquez, Miguel A. and Fleming, Tom P. (2016) DOHaD and the periconceptional period, a critical window in time. In, The Epigenome and Developmental Origins of Health and Disease. London, GB. Academic Press, pp. 33-47. (doi:10.1016/B978-0-12-801383-0.00003-7).

Record type: Book Section

Abstract

Environmental conditions can modulate the developmental program and have enduring consequences on the life cycle, affecting long-term health and disease risk through to adulthood. These effects can occur through different mechanisms and at different stages of development. This chapter considers environmental factors that may occur during the periconceptional period, around the time of conception and during early embryo development, and have lasting effects on phenotype and lifetime health. We review in particular in vivo conditions of maternal dietary nutrition during periconceptional development, both poor and over-rich nutrition, and how such conditions may affect the early embryo, altering subsequent development and postnatal health. In addition, in vitro conditions that embryos may experience, in particular associated with assisted conception technologies, are reviewed. We also evaluate the importance of paternal as well as maternal environment during periconceptional induction of developmental programming. We conclude that the periconceptional environment is one of critical sensitivity for lifetime health and there is a need for continued research within this field to identify mechanisms and devise protective strategies.

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Published date: 2016
Organisations: Centre for Biological Sciences

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Local EPrints ID: 402976
URI: http://eprints.soton.ac.uk/id/eprint/402976
PURE UUID: 81ccdc8a-f186-4dc7-b484-dd0a738d43ab

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Date deposited: 21 Nov 2016 13:53
Last modified: 15 Jul 2019 19:53

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