Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies
Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies
Data supporting:
Clarke, Harriet et al (2016) Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies. Journal of the American Chemical Society.
Fluoride has been overlooked as a target in the development of synthetic anion transporters despite natural fluoride transport channels being recently discovered. In this paper we report the direct measurement of fluoride bilayer transport facilitated by a series of strapped calix[4]pyrroles and show that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the inter-ference of naturally occurring fatty acids with the transport process and Cl- over H+/OH- transport selectivity
University of Southampton
Clarke, Harriet, Jane
f5c240ce-625a-47b4-a835-8b7cb44681d2
HOWE, ETHAN NW
be05ae9a-02e0-443b-97b2-d65cc387af40
WU, XIN
7c9d888f-abe1-4332-a26a-c850d220164c
Sommer, Fabian
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Yano, Masafumi
feec7c9e-6bff-47fd-88d6-3ac47deeb8e6
Light, Mark
cf57314e-6856-491b-a8d2-2dffc452e161
Kubik, Stefan
a6966f22-2ddf-409a-afc9-952299a83a48
Gale, Philip
c840b7e9-6847-4843-91af-fa0f8563d943
Clarke, Harriet, Jane
f5c240ce-625a-47b4-a835-8b7cb44681d2
HOWE, ETHAN NW
be05ae9a-02e0-443b-97b2-d65cc387af40
WU, XIN
7c9d888f-abe1-4332-a26a-c850d220164c
Sommer, Fabian
45aecf6d-63ff-4530-8deb-27d8a5b36604
Yano, Masafumi
feec7c9e-6bff-47fd-88d6-3ac47deeb8e6
Light, Mark
cf57314e-6856-491b-a8d2-2dffc452e161
Kubik, Stefan
a6966f22-2ddf-409a-afc9-952299a83a48
Gale, Philip
c840b7e9-6847-4843-91af-fa0f8563d943
Clarke, Harriet, Jane, HOWE, ETHAN NW, WU, XIN, Sommer, Fabian, Yano, Masafumi, Light, Mark, Kubik, Stefan and Gale, Philip
(2016)
Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies.
University of Southampton
doi:10.5258/SOTON/403025
[Dataset]
Abstract
Data supporting:
Clarke, Harriet et al (2016) Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies. Journal of the American Chemical Society.
Fluoride has been overlooked as a target in the development of synthetic anion transporters despite natural fluoride transport channels being recently discovered. In this paper we report the direct measurement of fluoride bilayer transport facilitated by a series of strapped calix[4]pyrroles and show that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the inter-ference of naturally occurring fatty acids with the transport process and Cl- over H+/OH- transport selectivity
Archive
Dataset_Transmembrane_Fluoride_Transport.zip
- Dataset
More information
Published date: 2016
Organisations:
Chemistry, FIMS, Chemistry Research Support, Characterisation and Analytics
Projects:
Supramolecular Chemistry and Transmembrane Anion Transport
Funded by: UNSPECIFIED (1499036)
1 October 2014 to 30 September 2017
Identifiers
Local EPrints ID: 403025
URI: http://eprints.soton.ac.uk/id/eprint/403025
PURE UUID: 0dc185f3-ced2-4f51-968c-572ded916992
Catalogue record
Date deposited: 23 Nov 2016 16:04
Last modified: 05 Nov 2023 02:37
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Contributors
Creator:
Harriet, Jane Clarke
Creator:
ETHAN NW HOWE
Creator:
XIN WU
Creator:
Fabian Sommer
Creator:
Masafumi Yano
Creator:
Stefan Kubik
Creator:
Philip Gale
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