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Detecting white matter injury in young patients with sickle cell disease using voxel-based morphometry

Detecting white matter injury in young patients with sickle cell disease using voxel-based morphometry
Detecting white matter injury in young patients with sickle cell disease using voxel-based morphometry
Objective: Sickle cell disease (SCD) is associated with cerebrovascular disease, cerebral infarction, and cognitive dysfunction. This study aimed to detect the presence and extent of white matter abnormalities in individuals with SCD using voxel-based morphometry (VBM).
Methods: Thirty-six children and adolescents with SCD (age range, 9-24 years) and 31 controls (8-25 years) underwent magnetic resonance investigations using T1- and T2-weighted protocols. White and gray matter density maps were obtained from three-dimensional magnetic resonance imaging (MRI) data sets. Using VBM, we compared the maps between controls and SCD individuals with silent white matter infarct lesions (SCD+L; n = 16), and those without visible abnormality (SCD-L; n = 20).
Results: In comparison with controls, intelligence quotients (IQs) were lower in both SCD groups irrespective of presence of visible lesions. VBM showed widespread bilateral white matter abnormalities in the SCD+L group, extending beyond the regions of focal infarction in the deep anterior and posterior white matter borderzones. Bilateral white matter abnormalities were also observed in the SCD-L group, in locations similar to those in the SCD+L group.
Interpretation: VBM is sensitive to detection of widespread white matter injury in SCD patients in borderzones between arterial territories even in the absence of evidence of infarction. Those changes may contribute to cognitive deficits in this population.
0364-5134
662-672
Baldeweg, T.
ce2161fc-17c9-4fbc-9c22-85e2e70d46c6
Hogan, A.M.
42ccf5b5-98d7-4ce7-b09a-ea482dfe8447
Saunders, D.
7bbacd4a-c47f-49ef-a82f-92cdb08c00f2
Telfer, P.
2a7a05d9-a0db-4511-9c82-822f98e3aa12
Gadian, D.
09b1c7df-2ea3-442d-8332-933404ae27f6
Vargha-Khadem, F.
9d4adb9c-2fb3-46c4-9dbb-f3b8052b5036
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Baldeweg, T.
ce2161fc-17c9-4fbc-9c22-85e2e70d46c6
Hogan, A.M.
42ccf5b5-98d7-4ce7-b09a-ea482dfe8447
Saunders, D.
7bbacd4a-c47f-49ef-a82f-92cdb08c00f2
Telfer, P.
2a7a05d9-a0db-4511-9c82-822f98e3aa12
Gadian, D.
09b1c7df-2ea3-442d-8332-933404ae27f6
Vargha-Khadem, F.
9d4adb9c-2fb3-46c4-9dbb-f3b8052b5036
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Baldeweg, T., Hogan, A.M., Saunders, D., Telfer, P., Gadian, D., Vargha-Khadem, F. and Kirkham, F. (2006) Detecting white matter injury in young patients with sickle cell disease using voxel-based morphometry. Annals of Neurology, 59 (4), 662-672.

Record type: Article

Abstract

Objective: Sickle cell disease (SCD) is associated with cerebrovascular disease, cerebral infarction, and cognitive dysfunction. This study aimed to detect the presence and extent of white matter abnormalities in individuals with SCD using voxel-based morphometry (VBM).
Methods: Thirty-six children and adolescents with SCD (age range, 9-24 years) and 31 controls (8-25 years) underwent magnetic resonance investigations using T1- and T2-weighted protocols. White and gray matter density maps were obtained from three-dimensional magnetic resonance imaging (MRI) data sets. Using VBM, we compared the maps between controls and SCD individuals with silent white matter infarct lesions (SCD+L; n = 16), and those without visible abnormality (SCD-L; n = 20).
Results: In comparison with controls, intelligence quotients (IQs) were lower in both SCD groups irrespective of presence of visible lesions. VBM showed widespread bilateral white matter abnormalities in the SCD+L group, extending beyond the regions of focal infarction in the deep anterior and posterior white matter borderzones. Bilateral white matter abnormalities were also observed in the SCD-L group, in locations similar to those in the SCD+L group.
Interpretation: VBM is sensitive to detection of widespread white matter injury in SCD patients in borderzones between arterial territories even in the absence of evidence of infarction. Those changes may contribute to cognitive deficits in this population.

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Published date: 2006

Identifiers

Local EPrints ID: 40304
URI: https://eprints.soton.ac.uk/id/eprint/40304
ISSN: 0364-5134
PURE UUID: a1f572ef-c731-4b48-85b6-761b419e052f

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Date deposited: 04 Jul 2006
Last modified: 30 Sep 2017 20:51

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