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Design and cellular fate of bioinspired Au–Ag nanoshells@hybrid silica nanoparticles

Design and cellular fate of bioinspired Au–Ag nanoshells@hybrid silica nanoparticles
Design and cellular fate of bioinspired Au–Ag nanoshells@hybrid silica nanoparticles
Silica-coated gold–silver alloy nanoshells were obtained via a bioinspired approach using gelatin and poly-l-lysine (PLL) as biotemplates for the interfacial condensation of sodium silicate solutions. X-ray photoelectron spectroscopy was used as an efficient tool for the in-depth and complete characterization of the chemical features of nanoparticles during the whole synthetic process. Cytotoxicity assays using HaCaT cells evidenced the detrimental effect of the gelatin nanocoating and significant induction of late apoptosis after silicification. In contrast, PLL-modified nanoparticles had less biological impact that was further improved by the silica layer, and uptake rates of up to 50% of those of the initial particles could be achieved. These results are discussed considering the effect of nanosurface confinement of the biopolymers on their chemical and biological reactivity.
0743-7463
10073-10082
Soule, Samantha
f5b1ff97-bf20-4adb-ba1d-357254158d8f
Bulteau, Anne-Laure
87819ae7-7846-4951-816d-0c0c9f0d3e7b
Faucher, Stéphane
ebfe7ac9-bc91-4921-bf2f-b053e4cb6278
Haye, Bernard
38d5dcd3-d7ff-4075-aaf2-43e4a1062630
Aimé, Carole
c477c83e-1522-4ae6-a78e-526b57835be9
Allouche, Joachim
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Dupin, Jean-Charles
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Lespes, Gaëtane
0ab2ac02-f82a-4979-a32c-52503b04ea63
Coradin, Thibaud
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Martinez, Hervé
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Soule, Samantha
f5b1ff97-bf20-4adb-ba1d-357254158d8f
Bulteau, Anne-Laure
87819ae7-7846-4951-816d-0c0c9f0d3e7b
Faucher, Stéphane
ebfe7ac9-bc91-4921-bf2f-b053e4cb6278
Haye, Bernard
38d5dcd3-d7ff-4075-aaf2-43e4a1062630
Aimé, Carole
c477c83e-1522-4ae6-a78e-526b57835be9
Allouche, Joachim
ba9f77b5-8142-4630-8d4b-5a8adcc99ef9
Dupin, Jean-Charles
e9c9571a-39e6-47a9-8a2a-9b25d045890c
Lespes, Gaëtane
0ab2ac02-f82a-4979-a32c-52503b04ea63
Coradin, Thibaud
5c457dfa-0949-4c11-8e32-0b4057907ed3
Martinez, Hervé
d10bc13d-2b6c-4826-876e-9d5c3874b3c0

Soule, Samantha, Bulteau, Anne-Laure, Faucher, Stéphane, Haye, Bernard, Aimé, Carole, Allouche, Joachim, Dupin, Jean-Charles, Lespes, Gaëtane, Coradin, Thibaud and Martinez, Hervé (2016) Design and cellular fate of bioinspired Au–Ag nanoshells@hybrid silica nanoparticles. Langmuir, 32 (39), 10073-10082. (doi:10.1021/acs.langmuir.6b02810).

Record type: Article

Abstract

Silica-coated gold–silver alloy nanoshells were obtained via a bioinspired approach using gelatin and poly-l-lysine (PLL) as biotemplates for the interfacial condensation of sodium silicate solutions. X-ray photoelectron spectroscopy was used as an efficient tool for the in-depth and complete characterization of the chemical features of nanoparticles during the whole synthetic process. Cytotoxicity assays using HaCaT cells evidenced the detrimental effect of the gelatin nanocoating and significant induction of late apoptosis after silicification. In contrast, PLL-modified nanoparticles had less biological impact that was further improved by the silica layer, and uptake rates of up to 50% of those of the initial particles could be achieved. These results are discussed considering the effect of nanosurface confinement of the biopolymers on their chemical and biological reactivity.

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Accepted/In Press date: 7 September 2016
e-pub ahead of print date: 8 September 2016
Published date: 4 October 2016
Organisations: Chemistry

Identifiers

Local EPrints ID: 403256
URI: http://eprints.soton.ac.uk/id/eprint/403256
ISSN: 0743-7463
PURE UUID: c3ad63ce-d043-4865-ab7c-34579e77b34a

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Date deposited: 29 Nov 2016 11:34
Last modified: 06 Oct 2020 22:11

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Contributors

Author: Samantha Soule
Author: Anne-Laure Bulteau
Author: Stéphane Faucher
Author: Bernard Haye
Author: Carole Aimé
Author: Joachim Allouche
Author: Jean-Charles Dupin
Author: Gaëtane Lespes
Author: Thibaud Coradin
Author: Hervé Martinez

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