Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
We have demonstrated two radiofrequency pulse methods which convert the nuclear singlet order of proton spin pairs into the magnetisation of nearby 13C nuclei. These irradiation schemes work well in the near-equivalence regime of the three-spin system, which applies when the difference in the two 1H-13C couplings is much smaller than the 1H-1H coupling. We use pulse sequences to generate thermally polarized singlet states in a reproducible manner, and study the singlet-to-magnetisation transfer step. Preliminary results demonstrate a parahydrogen-enhanced 13C polarization level of at least 9%, providing a signal enhancement factor of more than 9000, using 50% enriched parahydrogen.
163-172
Eills, James
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Stevanato, Gabriele
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Bengs, Christian
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Gloggler, Stefan
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Elliott, Stuart
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Alonso Valdesueiro, Javier
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Pileio, Giuseppe
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Levitt, Malcolm
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January 2017
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Stevanato, Gabriele
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Bengs, Christian
6d086f95-d3e8-4adc-86a5-6b255aee4dd1
Gloggler, Stefan
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Elliott, Stuart
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Alonso Valdesueiro, Javier
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Pileio, Giuseppe
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Levitt, Malcolm
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Eills, James, Stevanato, Gabriele, Bengs, Christian, Gloggler, Stefan, Elliott, Stuart, Alonso Valdesueiro, Javier, Pileio, Giuseppe and Levitt, Malcolm
(2017)
Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems.
Journal of Magnetic Resonance, 274, .
(doi:10.1016/j.jmr.2016.11.010).
Abstract
We have demonstrated two radiofrequency pulse methods which convert the nuclear singlet order of proton spin pairs into the magnetisation of nearby 13C nuclei. These irradiation schemes work well in the near-equivalence regime of the three-spin system, which applies when the difference in the two 1H-13C couplings is much smaller than the 1H-1H coupling. We use pulse sequences to generate thermally polarized singlet states in a reproducible manner, and study the singlet-to-magnetisation transfer step. Preliminary results demonstrate a parahydrogen-enhanced 13C polarization level of at least 9%, providing a signal enhancement factor of more than 9000, using 50% enriched parahydrogen.
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Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
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Accepted/In Press date: 19 November 2016
e-pub ahead of print date: 1 December 2016
Published date: January 2017
Organisations:
Magnetic Resonance
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Local EPrints ID: 403334
URI: http://eprints.soton.ac.uk/id/eprint/403334
PURE UUID: b6f16cda-eb66-4c99-8bf7-637bc87fb67b
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Date deposited: 30 Nov 2016 10:13
Last modified: 16 Mar 2024 03:47
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Author:
James Eills
Author:
Gabriele Stevanato
Author:
Christian Bengs
Author:
Stefan Gloggler
Author:
Stuart Elliott
Author:
Javier Alonso Valdesueiro
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