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Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems

Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
We have demonstrated two radiofrequency pulse methods which convert the nuclear singlet order of proton spin pairs into the magnetisation of nearby 13C nuclei. These irradiation schemes work well in the near-equivalence regime of the three-spin system, which applies when the difference in the two 1H-13C couplings is much smaller than the 1H-1H coupling. We use pulse sequences to generate thermally polarized singlet states in a reproducible manner, and study the singlet-to-magnetisation transfer step. Preliminary results demonstrate a parahydrogen-enhanced 13C polarization level of at least 9%, providing a signal enhancement factor of more than 9000, using 50% enriched parahydrogen.
163-172
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Stevanato, Gabriele
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Bengs, Christian
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Gloggler, Stefan
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Elliott, Stuart
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Alonso Valdesueiro, Javier
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Pileio, Giuseppe
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Levitt, Malcolm
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Stevanato, Gabriele
13f2e0a2-2ce7-4938-a2ac-274a81196a72
Bengs, Christian
6d086f95-d3e8-4adc-86a5-6b255aee4dd1
Gloggler, Stefan
e6b46e9a-8594-4c5a-bced-e2c2f946c390
Elliott, Stuart
6cc724de-f75f-4c0f-a00a-e712b4e73b12
Alonso Valdesueiro, Javier
ee87ede4-2a13-4e6e-af22-bda1d4c83517
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Levitt, Malcolm
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3

Eills, James, Stevanato, Gabriele, Bengs, Christian, Gloggler, Stefan, Elliott, Stuart, Alonso Valdesueiro, Javier, Pileio, Giuseppe and Levitt, Malcolm (2017) Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems. Journal of Magnetic Resonance, 274, 163-172. (doi:10.1016/j.jmr.2016.11.010).

Record type: Article

Abstract

We have demonstrated two radiofrequency pulse methods which convert the nuclear singlet order of proton spin pairs into the magnetisation of nearby 13C nuclei. These irradiation schemes work well in the near-equivalence regime of the three-spin system, which applies when the difference in the two 1H-13C couplings is much smaller than the 1H-1H coupling. We use pulse sequences to generate thermally polarized singlet states in a reproducible manner, and study the singlet-to-magnetisation transfer step. Preliminary results demonstrate a parahydrogen-enhanced 13C polarization level of at least 9%, providing a signal enhancement factor of more than 9000, using 50% enriched parahydrogen.

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Accepted/In Press date: 19 November 2016
e-pub ahead of print date: 1 December 2016
Published date: January 2017
Organisations: Magnetic Resonance

Identifiers

Local EPrints ID: 403334
URI: https://eprints.soton.ac.uk/id/eprint/403334
PURE UUID: b6f16cda-eb66-4c99-8bf7-637bc87fb67b
ORCID for Giuseppe Pileio: ORCID iD orcid.org/0000-0001-9223-3896
ORCID for Malcolm Levitt: ORCID iD orcid.org/0000-0001-9878-1180

Catalogue record

Date deposited: 30 Nov 2016 10:13
Last modified: 14 Jul 2018 00:34

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