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Towards AMR testing using paper-based diagnostic sensors

Towards AMR testing using paper-based diagnostic sensors
Towards AMR testing using paper-based diagnostic sensors
Overuse of broad spectrum antimicrobial agent means that resistance to them can evolve rapidly in microbe populations, and hence when a broad spectrum treatment is really crucial, it is less effective at saving the patient. Furthermore, once the bacteria become resistant, it can then exacerbate the prevalence of antibiotic resistance. Current routine empirical antibiotic therapy protocol involves laboratory based bacterial culture testing which can take up to 2-3 days. As a result, the only option available to the clinician is the treatment of the patient using an empirical antibiotic prescription. Such treatments can either prove to be ineffective, or potentially worsen the patient’s condition.
However, if the specific microbe species causing an infection can be quickly identified earlier on, it will allow doctors to prescribe a specific targeted antimicrobial instead of using a broad spectrum antimicrobial. Therefore, early diagnosis and prompt correct antibiotic treatment is important for clinical recovery and prevention of this serious antibiotic resistance. In this work, we will present our preliminary results on the use of a laser-based fabrication technique in the development of paper-based diagnostic tests which are analogues of the commonly available pregnancy 'dipstick' testing kits, and which will allow the timely detection of multiple pathogens at the point-of-care, either in the clinic or in the community. These paper-based diagnostic sensors fabricated via our laser-based technology are cheap, easy-to-use and allow rapid testing of either pathogens or their antimicrobial resistance to antibiotics.
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Sones, Collin
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
Eason, Robert
e38684c3-d18c-41b9-a4aa-def67283b020
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Sones, Collin
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
Eason, Robert
e38684c3-d18c-41b9-a4aa-def67283b020

Katis, Ioannis, He, Peijun, Sones, Collin and Eason, Robert (2016) Towards AMR testing using paper-based diagnostic sensors. SfAM Antimicrobial Resistance Meeting, London, United Kingdom. 24 Nov 2016.

Record type: Conference or Workshop Item (Other)

Abstract

Overuse of broad spectrum antimicrobial agent means that resistance to them can evolve rapidly in microbe populations, and hence when a broad spectrum treatment is really crucial, it is less effective at saving the patient. Furthermore, once the bacteria become resistant, it can then exacerbate the prevalence of antibiotic resistance. Current routine empirical antibiotic therapy protocol involves laboratory based bacterial culture testing which can take up to 2-3 days. As a result, the only option available to the clinician is the treatment of the patient using an empirical antibiotic prescription. Such treatments can either prove to be ineffective, or potentially worsen the patient’s condition.
However, if the specific microbe species causing an infection can be quickly identified earlier on, it will allow doctors to prescribe a specific targeted antimicrobial instead of using a broad spectrum antimicrobial. Therefore, early diagnosis and prompt correct antibiotic treatment is important for clinical recovery and prevention of this serious antibiotic resistance. In this work, we will present our preliminary results on the use of a laser-based fabrication technique in the development of paper-based diagnostic tests which are analogues of the commonly available pregnancy 'dipstick' testing kits, and which will allow the timely detection of multiple pathogens at the point-of-care, either in the clinic or in the community. These paper-based diagnostic sensors fabricated via our laser-based technology are cheap, easy-to-use and allow rapid testing of either pathogens or their antimicrobial resistance to antibiotics.

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More information

Published date: 24 November 2016
Venue - Dates: SfAM Antimicrobial Resistance Meeting, London, United Kingdom, 2016-11-24 - 2016-11-24
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 403406
URI: http://eprints.soton.ac.uk/id/eprint/403406
PURE UUID: 9109c7f7-a461-4a59-94e0-3c186b280ef4
ORCID for Ioannis Katis: ORCID iD orcid.org/0000-0002-2016-557X
ORCID for Robert Eason: ORCID iD orcid.org/0000-0001-9704-2204

Catalogue record

Date deposited: 30 Nov 2016 12:38
Last modified: 18 Feb 2021 17:23

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Contributors

Author: Ioannis Katis ORCID iD
Author: Peijun He
Author: Collin Sones
Author: Robert Eason ORCID iD

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